Biological and Pharmaceutical Complex Fluids II: Novel Trends in Characterizing Interactions, Microstructure and Rheology

An ECI Conference Series

August 10-14, 2014
Durham, North Carolina, USA

Call for Abstracts!

Oral Abstracts Submission Deadline:  Closed
Poster Abstracts Submission Deadline:  July 8, 2014

Poster Size:  4 ft high x 8 ft wide

                      Preliminary Program                             Poster Presentations             

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About This Conference

SynopsisBiotherapeutics or biologics are rapidly emerging as the next generation of therapeutic solutions for many life threatening diseases in the areas of unmet medical need. This sector is expected to continue its significant growth over the next decade as rapid development of recombinant proteins and peptides along with identification of newer targeting approaches lead to augmentation or replacement of small organic molecules with therapeutic proteins. Developing stable formulations with these biological complex fluids comes with its own set of challenges as complex specific and non-specific interactions can lead to self-association, irreversible aggregate formation, and other manifestations that negatively impact physicochemical properties and delivery. These in turn lead to issues in formulation storage stability, high viscosity and associated issues in manufacturing and injectability etc. Similar to other complex fluids, these biological complex fluids also exhibit rich interfacial and surface properties leading to structuring and interactions with air/water and solid/water interfaces.

Understanding and establishing the structure-property relationships in such systems and understanding interactions in complex biopharmaceutical formulations is, therefore, key to designing stable new therapeutic solutions and novel drug delivery mechanisms. However, most of these systems have their unique characterization challenges such as, small sample volumes, high sensitivity to any applied shear, external conditions etc. Also it is of primary importance to characterize the microstructure and interactions either in-vivo or in environments that very closely mimic the biological environment of interest. The need to characterize such complex fluids/soft matter systems also extends to other industrial sectors such as foods and some of the characterization challenges and limitations of current techniques remain quite similar across biopharmaceuticals & foods.

These challenges have led to a number of different developments in novel characterization techniques, ranging from particle tracking microrheology to microfluidics and MEMS-based techniques. A key challenge in proper application/refinement of these techniques/devices and the development of new ones lies in the ability to adequately understand the requirements from an industrial application perspective and ensure that the generated insights enrich our fundamental understanding required for generation of design rules for product & process (therapeutic protein solutions, food systems etc).

This meeting, the second in this ECI series, will focus on bringing together a wide range of multi-disciplinary groups from academia and industry with a view to discussing key challenges, recent developments, and future trends in characterization of biological complex fluids with a specific focus on the Biotherapeutics & Foods industrial sectors.

It is expected that this will lead to significant cross-industry learning and potential new cross-industry collaborations.  Some of the key areas of focus for the meeting will be novel techniques/methods focused on the characterization of:

  • Conformational and Colloidal Stability
  • Charge and Electrostatic Interactions
  • Protein-Protein Interactions
  • Protein Aggregation-Thermodynamics, Kinetics & Interactions
  • Protein Rheology and Microrheology in Bulk
  • Protein Structuring and Rheology at Interfaces
  • Micro/mesostructure in Self-Associated Biological Complex Fluids

In addition, there will be an industry-focused session on:

  • Industrial Challenges for Protein-based Formulations

Some of the key emerging techniques which will be discussed in the context of these applications will include (non-exhaustive list)

  • Scattering-Light (SLS/DLS), Neutrons (SANS/Reflectometry) & X-ray (SAXS)
  • Microrheometry-passive & active tracer microrheology, microfluidic/microcantilever microviscometry
  • Interfacial Rheological Techniques
  • Novel developments in Interfacial Characterization
  • Spectroscopy-Raman, Florescence, IR, SERS.
  • Capillary Electrophoresis, Electrophoretic Light Scattering, Membrane Confined Electrophoresis,  Dielectrophoresis
  • NMR & PGSE-NMR
  • Particle Sizing-DLS, Particle Tracking, Flow Imaging, Optical Tweezers
  • Novel Hybrid Techniques
  • Theoretical Developments

Confirmed Speakers  (partial list – additional speakers will be posted here as they are confirmed.)
-Andreas Bommarius (Georgia Tech, USA).
-Ralph Colby (Penn State, USA)
-Joseph Curtis (NIST, USA)
-Dganit Danino (Technion, Isreal)
-Nicholas Darton (Arecor, UK)
-Aristide Dogariu (University of Central Florida, USA)
-David Ericksson (Cornell University, USA)
-Micheal Fitzgerald (Duke University, USA)
-Gerald Fuller (Stanford University, USA)
-Eric Furst (University of Delaware, USA)
-Zhongwei Gu (National Engineering Research Center for Biomaterials, China)
Saad Khan (NC State, USA)
-Jian Lu (University of Manchester, UK)
-Michael Marlow (Regeneron, USA)
-Jai Pathak (Medimmune, USA)
-Srini Raghavan (University of Maryland, USA)
-Dieter Richter (Juelich Center for Neutron Science, Germany)
-Dean Ripple (NIST, USA)
-Kathleen Stebe (University of Pennsylvania, USA)
-Anna Stradner (Lund University, Sweden)
-Orlin Velev (NC State, USA)
-Bente Vestergaard (University of Copenhagen, Denmark)

Conference Organization

Conference Chairs

Dr. Samiul Amin, Malvern Instruments, USA
Email: samiul.amin@malvern.com T: 1-443-878-1325

Dr. Tapan Das, Center of Excellence for Mass Spectrometry and Biophysics, Biologics Development, Bristol Myers Squibb, USA
Email: tapan.das@bms.com, T+1-609-818-4308

Scientific Steering Committee

Dr. Jordan Petkov, Unilever R&D, UK
Professor Peter Schurtenberger, Lund University, Sweden
Dr. Steven Hudson, National Institute of Standards and Technology (NIST), USA
Professor Christopher Roberts, University of Delaware, USA
Professor John Carpenter, Co-Director of the Center for Pharmaceutical Biotechnology, University of Colorado School of Pharmacy, USA
Dr. Mary Cromwell, Director and Senior Scientist, Late Stage Pharmaceutical Development Department, Genentech, USA
Professor Christopher Daubert, Head: Food, Bioprocessing and Nutrition Sciences, North Carolina State University, North Carolina, USA
Professor Yatin Gokarn, Institute of Chemical Technology (Mumbai), India

Conference Sponsors

Click on the logo to view the sponsor website. 

 

Abstract Submission

One-page abstracts that include specific results and conclusions to allow a scientific assessment of a proposed oral presentation or poster are invited.

Early stage researchers/students are strongly encouraged to submit abstracts for the poster session.

Oral Abstracts Submission Deadline:  Closed
Poster Abstracts Submission Deadline:  July 8, 2014

Poster Size: 4 ft high x 8 ft wide

Abstracts should be submitted electronically at https://ssl.linklings.net/conferences/complexfluids/

The abstract template available at the above link must be followed for an abstract to be considered for presentation.

Conference Venue

Washington Duke Inn:  Located on the campus of Duke University, the Washington Duke Inn & Golf Club is an Award-winning hotel like no other in the region. Built in the style of an old English country inn the hotel is nestled on a 300-acre site and situated in the heartland of North Carolina. The Inn features the Duke University Golf Course, 271 elegantly appointed guest rooms and suites, the award-winning Fairview Dining Room and the Bull Durham Bar.  The Inn is convenient to all points in the Research Triangle area and downtown Durham.  Directions to the Inn.

Washington Duke Inn has a golf course, an indoor pool, and a health club. This 4-star hotel features business amenities including a business center, small meeting rooms, and limo/town car service. Additional amenities include spa services, gift shops/newsstands, and coffee/tea in the lobby. Guest parking is complimentary. This is a smoke-free property.

Durham, North Carolina  The term “Triangle” was first coined to refer to an area anchored by three major universities: Duke University in Durham (and later North Carolina Central University), the University of North Carolina in Chapel Hill and North Carolina State University in Raleigh. The three joined in the 1950’s to help create Research Triangle Park, centered in southeast Durham. Today, the term is used to refer to a five-county metropolitan statistic area or census laborshed, or a 3,000 square mile, six-county, 26-community planning region.

Durham is most well known for being the home of Duke University, and its many attractions including the Nasher  Museum of Art, sports events, and the Duke Lemur Center, which hosts the largest collection of lemurs outside of Madagascar. The Durham Performing Arts Center puts on a number of performances throughout the year including Broadway shows. The Museum of Life and Science contains a number of interactive science-related exhibits, as does the Marbles Kids Museum, a hands-on, interactive place that inspires children to be active learners.

At the Sarah P. Duke Gardens on Duke University’s West Campus one can discover exotic blooms as well as local beauties growing side by side. Just beyond the gardens, you’ll find the beautiful Duke Chapel. Duke’s West Campus is also home to the magnificent Nasher Museum of Art whose galleries feature many local artists as well as exhibits on national tours.

North Carolina wine can be tasted at a local vineyard, Rock of Ages Winery. For a different tasting experience, visit the Triangle Brewery in downtown Durham. Sample their Belgian and American style brews and request a tour of the brewery.

For baseball fans the minor-league  Durham Bulls play at the Durham Bulls Athletic Park. The baseball stadium is surrounded by the restored warehouses of the American Tobacco Campus.

Durham also boasts many wonderful restaurants thanks to a thriving colony of imaginative chefs. The town has been ranked as the “Foodiest Small Town in America.” Nearly 40 Durham restaurants and chefs have earned reputations in high profile media sources such as Bon Appétit, Gourmet, The New York Times, and Food & Wine.  To search for a restaurant visit http://www.durham-nc.com/dining/

For further information about the area please visit the following links:

Durham Convention and Visitors Bureau: http://www.durham-nc.com/about/index.php

Top attractions (a pdf file): http://www.dcvb-nc.com/comm/snapshots_flyer.pdf

Wikipedia page: http://en.wikipedia.org/wiki/Durham,_North_Carolina

36 Hours in Raleigh, NC

Travel Information

The Washington Duke Inn is located just 20 minutes from Raleigh-Durham International Airport.

For driving directions see here: http://www.washingtondukeinn.com/About Us/directions.asp

For information on ground transportation including taxis, shuttles  and private cars visit http://www.rdu.com/groundtrans/transvcs.html

Entry visas for USA
If you require a visa to enter the USA, please visit the website of The National Academies for the most current, detailed information regarding traveling to the United States. http://www.nationalacademies.org/visas/Traveling_to_US.html

National Academies International Visitor Office If you have applied for a visa and are having difficulties, please contact the National Academies International Visitors Office and complete a questionnaire to request assistance. U.S. State Department

If you require a special letter of invitation from ECI, please send an e-mail to info@engconfintl.org and we will send you an information form to complete.

Fees and Registration

Conference Fees

All conference fees are inclusive. They include registration, accommodations (Sunday, Monday, Tuesday and Wednesday nights) and meals (excluding dinner on Tuesday and lunch on Wednesday), taxes, and gratuities from the reception on Sunday through breakfast on Thursday. Incidental fees (telephone calls, faxes, laundry, etc.) are billed to your personal account by the hotel.

ALL PARTICIPANTS (INCLUDING MEMBERS OF THE ORGANIZING COMMITTEE AND INVITED SPEAKERS) ARE REQUIRED TO REGISTER.

The conference fees are:

 

Register on or before July 9, 2014

Register after July 9, 2014

Participant (single occupancy or sharing room with a guest; guest fee additional)

US $2,000.00

US $2,200.00

Participant (sharing a room with another participant)

US $1,654.00

US $1,854.00

Bona fide Graduate Student (sharing a room with another student) (Those in this category must send proof of current status – copy of current Student ID can be faxed to 1-212-514-6030 or emailed to Kathy@engconfintl.org)

US $1,240.00

US $1,440.00

**Fees for Guest/accompanying person sharing bedroom with single occupancy participant. (All conference-included meals and receptions, including the banquet)

US $490.00

US $490.00

Local residents who do not require accommodations may contact ECI (Kathy@engconfintl.org) for pricing with the cost of lodging excluded.

 If you plan to bring children to the conference, please contact ECI (Kathy@engconfintl.org) for pricing.

Conference Registration

You will need a login name and password to register for ECI conferences through our online system. If you have been a recent participant at an ECI conference or have submitted an online application or request for information about an ECI Conference, you may already have an account with us. If you know your login information please use it. If you are not sure whether you already have a login and password, please click on automated password retrieval and enter your e-mail address before creating a new account. If we don’t have a valid email address on file for you, a pop up window will appear stating that no records were found. Click “OK” and then follow the instructions to create a new account. If you have any questions or experience any difficulties, please email tressa@engconfintl.org.

Special Notes and Payment Instructions

We suggest that you register as soon as possible to be certain that you will have a hotel room at the conference rate.  Late registrations will be accepted on a space available basis.

All participants are encouraged to register before June 27, 2014.  There is a discounted price for registering before this date and hotel space cannot be guaranteed for registrations received after this date.  Your registration is not officially confirmed until we receive payment of the amount due and ECI reserves the right to cancel your room registration if payment is not received. Your invoice/receipt will automatically be e-mailed upon of receipt of your registration.

Because of contractual guarantees made with the hotel for room and meal functions, no shows, late arrivals, missed meals and early departures cannot receive fee adjustments.

Payment must be made by credit card (Visa, Mastercard, Amex), check or money order drawn on a U.S. bank in U.S. dollars, payable to ENGINEERING CONFERENCES INTERNATIONAL. Checks or money orders in any other currencies are NOT ACCEPTABLE.  Payment is made on the web site except for those who are sending payment by wire transfer or have a purchase order from their company/institution.

WIRE TRANSFER PAYMENT: If you are planning to make payment by wire transfer, please contact ECI for the bank information. You must add $30 to cover ECI bank charges. Please reference your full name and the conference title.  Fax a copy of your bank transfer papers to ECI (Fax: +1-212-514-6030) or email a scanned copy to kathy@engconfintl.org.  This is very important – otherwise it is extremely difficult to trace your payment and you may not receive a receipt prior to the conference.

Cancellation Policy: Cancellation must be received by ECI in writing at least three weeks prior to the start of the conference in order for a full refund to be considered. The ECI auditors require that refunds for all conference cancellations be processed after the conference so that the necessary back-up information (i.e., hotel list of those in-house) can be attached to the refund request and ECI can verify that the hotel has not charged a cancellation fee. Cancellations received less than three weeks prior to the conference start date are subject to a $200 cancellation fee plus any direct expenses incurred by ECI.

If you have a disability and may require accommodation in order to participate fully in this conference, please indicate this when you register. An ECI representative will contact you to discuss your specific needs. If you have special dietary requirements (e.g., vegetarian or a food allergy), please make a note on your registration card.  The chef needs to know this information in advance if we are to accommodate you.

Should you have specific questions regarding your registration, please contact Kathy Chan (Kathy@engconfintl.org).

 

Preliminary Program

 

Click HERE to view the preliminary program.

To receive more information and a call for abstracts, please Request for Next Mailing.

Sponsorship Opportunities

Click HERE to view the sponsorship opportunities for this conference.

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General Information

Engineering Conferences International (ECI) is a global engineering conferences program, originally established in 1962, that provides opportunities for the exploration of problems and issues of concern to engineers and scientists from many disciplines.

The format of the weeklong research conference provides morning and late afternoon or evening sessions in which major presentations are made. Available time is included during the afternoons for ad hoc meetings, informal discussions, and/or recreation. This format is designed to enhance rapport among participants and promote dialogue on the development of the meeting. We believe that the conferences have been instrumental in generating ideas and disseminating information to a greater extent than is possible through more conventional forums.

All participants are expected both to attend the entire conference and to contribute actively to the discussions. The recording of lectures and presentations is forbidden. As ECI conferences take place in an informal atmosphere, casual clothing is the usual attire.

The Engineering Conferences International conferences calendar and other information can be found on the ECI web site: www.engconfintl.org

Engineering Conferences International
32 Broadway, Suite 314, New York, NY 10004
T: 1-7212-514-6760 – F: 1-212-514-6030

info@engconfintl.org – www.engconfintl.org

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