Biological and Pharmaceutical Complex Fluids III: Protein Self-Assembly, Rheology and Interfacial Properties

An ECI Conference Series

July 14-18, 2019
Schloss Hernstein
Hernstein, Austria

Know Before You Go! — Important Information for Participants

Register Now!            Final Program

Call for Abstracts!   Deadlines:   Oral- Closed   Poster- May 15, 2019         

Visa Information for Austria

Please forward this link to colleagues who may be interested in the conference topic.

About This Conference

The focus of this conference is quite unique in that it brings together scientists in two very different industrial sectors: Biotherapeutics and Foods.  The common unifying theme being the challenges and progress made in these areas for characterizing complex fluids found commonly in both the sectors, such as proteins.

Biotherapeutics or biologics is rapidly emerging as the next generation of therapeutic solutions for many life-threatening diseases in the area of unmet medical needs.  This sector is expected to continue its significant growth over the next decade as rapid development of recombinant proteins and peptides, along with identification of new targeting approaches, leads to augmentation or replacement of small organic molecules with therapeutic proteins.  Developing stable formulations with these biological complex fluids comes with its own set of challenges as complex specific and non-specific interactions can lead to self-association, irreversible aggregate formation, and other manifestations that negatively impact physicochemical properties and delivery.

These, in turn, lead to issues in formulation storage stability, high viscosity and associated issues in manufacturing, injectability, etc.  Similar to other complex fluids, these biological complex fluids also exhibit rich interfacial and surface properties leading to structuring and interactions with air/water and solid/water interfaces.  Understanding and establishing the structure-property relationships in such systems and understanding interactions in complex biopharmaceutical formulations is, therefore, key to designing stable new therapeutic solutions and novel drug delivery mechanisms.  However, most of these systems have their unique characterization challenges such as small sample volumes, high sensitivity to any applied shear, external conditions, etc.

Also, it is of primary importance to characterize the microstructure and interactions either in vivo or in environments that very closely mimic the biological environment of interest.  The need to characterize and gain physicochemical insights into biological complex fluids/soft matter systems also extends to other industrial sectors such as foods, where proteins are utilized in products and similar insights into the microstructure, rheology and interfacial properties is critical in optimizing food product performance.

This meeting, the third in this ECI series, will focus on bringing together a wide range of multi-disciplinary groups from academia and industry with a view to discussing key challenges, recent developments, key insights and future trends in understanding protein aggregation, rheology and interfacial properties with a specific focus on formulations and products encountered in the biotherapeutics and foods industrial sectors.  It is expected that this will lead to significant cross-industry learning and potential new cross-industry collaborations.

Some of the key areas of focus for the meeting will be:

  • Protein-Protein interactions
  • Protein Aggregation-Thermodynamics, Kinetics and Interactions
  • Protein Rheology and Microrheology in Bulk
  • Protein Structuring and Rheology at Interfaces
  • Impact of Surfactants and Polymers on protein-based forumulatons
  • New Characterization Techniques

Click THIS LINK to visit the previous conference on this topic in 2014.

Confirmed Speakers

Komla Ako, CNRS/Grenoble, France
Michaela Blech, Boehringer Ingelheim, Germany
Guy Carpenter (Kings College, UK)
Luke Clifton (Rutherford Appleton Laboratory, UK)
Nicholas Darton (Arecor, UK)
Nikolai Denkov (University of Sofia, Bulgaria)
Vito Fodera, Copenhagen University, Denmark
Wolfgang Freiss (Ludwig-Maximilians-University of Munich, Germany)
Vitor Geraldes IST, University of Lisbon, Portugal
Christoph Grapentin, Lonza, Switzerland
Joel Karr, University of Colorado, USA
Clément de Loubens, CNRS/Grenoble, France
Mikael Lund, Lund University, Sweden
Cait MacPhee, University of Edinburgh, UK
Daniel Molnar, Boehringer Ingelheim, Germany
Malin Zackrissson Oskolkova, Novo Nordisk, Sweden
Karoline Bechhold Peters (Novartis, Switzerland)
Elke ScholtenWageningen University, Netherlands
Frank Schreiber , Uni Tuebingen, Germany
Ian Shieh (Genentech, USA)
Anna Stradner (Lund University, Sweden)
Marco van de Weert (Copenhagen University, Denmark)
Gerhard Winter, University of München, Germany
Emanuela Zaccarelli, Universita’ “La Sapienza” , Italy
Jingtao Zhang, Merck, USA

(as of 3/13/2019 — More to follow)

Conference Organization

Chairs:

Samiul Amin, Manhattan College, USA
Miguel Rodrigues, University of Lisbon, Portugal
Paolo Arosio, ETHZ, Switzerland

Organizing Committee:

Karin Anderson, Pfizer
Mark Auty, Mondalez, UK
Daniel G. Bracewell, University College London, UK
Robin Curtis, University of Manchester, UK
Tapan Das, Bristol-Myers Squibb, USA
Deniz Zeynal Gunes, Nestle, Switzerland
Michael Marlow, Boehringer-Ingelheim, USA
Christopher Roberts, University of Delaware, USA
Shahid Uddin, Medimmune, UK
Erik van der Linden, Wageningen University and Research, Netherlands

Abstract Submission

Please use the following key areas of focus to pre-select up to three sessions where you believe your work fits best:

  • Protein-Protein Interactions
  • Protein Aggregation-Thermodynamics, Kinetics and Interactions
  • Protein Rheology and Micro-rheology in Bulk
  • Protein Structuring and Rheology at Interfaces
  • Impact of Surfactants and Polymers on Protein-based Formulations
  • New Characterization Techniques

Abstracts (one page maximum) that include specific results and conclusions to allow a scientific assessment of the proposed oral presentation are invited.  Please prepared your abstract according to this template: docx or doc.

Abstracts must be submitted electronically using the template provided at THIS LINK.

Oral abstract submission deadline:                Closed

Poster abstract submission deadline:             May 15, 2019

Abstracts of all presentations will be made available to conference participants prior to the start of the conference.

Note: Only a limited number of oral presentation slots are available and thus all submissions for oral sessions will be considered for both oral and poster presentation.

ECI will sponsor awards for the outstanding student poster presentations.

Sponsor Levels

Please click on This Link to view the various levels of sponsorship.

Conference Venue

The conference will be held at Schloss Hernstein Seminar Hotel. The hotel is situated in the wonderful Triestingtal valley, surrounded by pine forests and a carp lake. Guests can enjoy sauna, steam and fitness rooms, as well as a large indoor swimming pool. There are also several signposted routes for jogging on forest tracks starting at the hotel.

Brochure describing the history of Schloss Hernstein:          Part I                    Part II

Hernstein Castle is situated at the fringe of the Viennese Basin, in the stepped footland of the Styrian and Lower Austrian limestone alps. Its history goes back to medieval times: once the castle safeguarded the street to Berndorf Village and the valley before it. In former times the building comprised a housing unit and a chapel. It would have been very difficult to expand the building; therefore a new castle – the core of today´s castle – was built in the valley at the foot of the mountain where the old castle had been built.

After the Turkish wars this new building was expanded and in the 18th century it got a uniform facade. For a long time the castle was owned by the Habsburgs and was used as domicile by Archduke Leopold Ludwig. The renowned architect Theophil Hansen designed the castle.

Hernstein Castle is one of the largest seminar hotels in Austria and is only available to seminar participants. Therefore it ensures a tranquil atmosphere of learning and working. Hernstein Castle has 74 modern bedrooms. Room amenities include sky and satellite TV, a minibar, work desk, and wireless internet.

Address:  Seminarhotel Schloss Hernstein, Berndorfer Strasse 32, 2560 Hernstein. Telephone:+43-2633 472510

Weather                      Activities in Austria

Transportation

The Vienna International Airport (VIE) is about 60 km from Schloss Hernstein or about 1 hour by car.

Driving Directions

By Train:  The S-Bahn (Rapid Transit) is an easy, economical means of travel between the airport and the Vienna Main Train Station (Wien Hauptbahnhof).  Railjet leaves every 30 min. for this 15 min. ride.  You can then take a RailEurope train from Vienna to Leobersdorf and then a taxi to Hernstein. Be certain to print out the map and directions in case the taxi driver in Vienna is not familiar with the rural area where Schloss Hernstein is located.

Conference Fees and Registration

Conference Fees

All conference fees are inclusive. They include registration, accommodations (Sunday, Monday, Tuesday, and Wednesday nights), all meals), drinks, and taxes from dinner on Sunday through lunch on Thursday. The hotel will bill Incidental fees (faxes, laundry, etc.) to your personal account.

ALL PARTICIPANTS (INCLUDING MEMBERS OF THE ORGANIZING COMMITTEE AND INVITED SPEAKERS) ARE REQUIRED TO REGISTER.

The conference fees are:

Register on or before June 14, 2019 Register after

June 14, 2019

Participant (single occupancy or sharing room with a guest; guest fee additional**) US $1685.00 US $1865.00
Participant (sharing a room with another participant) US $1559.00 US $1759.00
Bona fide Graduate Student (sharing a room with another student) (Those in this category must send proof of current status – copy of current Student ID can be faxed to 1-212-514-6030 or emailed to Kathy@engconfintl.org) US $1169.00 US $1169.00
**Fees for Guest/accompanying person sharing bedroom with single occupancy participant. (A guest badge will be issued and this fee Includes all conference meals and the wine-tasting reception.) US $630.00 US $630.00

If you plan to bring children to the conference, please contact ECI (info@engconfintl.org) for pricing.

Conference Registration

You will need a login name and password to register for ECI conferences through our online system. If you have been a recent participant at an ECI conference or have submitted an online application or request for information about an ECI Conference, you may already have an account with us. If you know your login information, please use it.

If you are not certain if you already have a login and password, please click on automated password retrieval and enter your e-mail address before creating a new account. If we do not have a valid email address on file for you, a pop up window will appear stating that no records were located. Click “OK” and then follow the instructions to create a new account.

If you have any questions or experience any difficulties, please email kathy@engconfintl.org.

Pre-and Post-Conference Reservations

If you are planning to arrive early (before July 14 or to stay after the conference (after July 18), you MUST make hotel reservations directly with the hotel.  Use the appropriate form on THIS PAGE to make your reservations.

If you have any questions or experience any difficulties, please email kathy@engconfintl.org

Special Notes for Payment

We suggest that you register as soon as possible to be certain that you will have a hotel room at the conference rate.  Late registrations will be accepted on a space available basis and late registrants may be housed in a nearby hotel.

All participants are encouraged to register before June 15, 2019.  There is a discounted price for registering before this date.  Hotel space cannot be guaranteed for registrations received after this date.  Your registration is not officially confirmed until we receive payment of the amount due.  ECI reserves the right to cancel your room registration if payment is not received. Your invoice/receipt will automatically be e-mailed upon of receipt of your registration.  Should you need a signed receipt, please contact Kathy Chan (kathy@engconfintl.org).

Because of contractual guarantees made with the hotel for room and meal functions, no shows, late arrivals, missed meals and early departures cannot receive fee adjustments.  If you have a disability and may require accommodation in order to participate fully in this conference, please indicate this when you register. An ECI representative will contact you to discuss your specific needs. If you have special dietary requirements (e.g., vegetarian or a food allergy), please make a note on your registration.  The chef needs to know this information in advance if we are to accommodate you. ECI will attempt to accommodate special requests such as Kosher or Halal meals, but such meals may not be available at all conference sites. The participant must pay any additional costs for special meal requests to ECI.

Payment must be made by credit card (Visa, MasterCard, and Amex), check or money order drawn on a U.S. bank in U.S. dollars, payable to ENGINEERING CONFERENCES INTERNATIONAL. Checks or money orders in any other currencies are NOT ACCEPTABLE.  Payment must be made on the web site except for those who are sending payment by wire transfer or have a purchase order from their company/institution.

WIRE TRANSFER PAYMENT: If you are planning to make payment by wire transfer, please contact ECI for the bank information. You must add $30 to cover ECI bank charges. Please reference your full name and the conference title.  Either fax a copy of your bank transfer papers to ECI (Fax: +1-212-514-6030) or email a scanned copy to kathy@engconfintl.org.  This is very important – otherwise it is extremely difficult to trace your payment and you may not receive a receipt prior to the conference.

Cancellation Policy: Cancellation must be received by ECI in writing at least 28 days prior to the start of the conference in order for a full refund (less a processing fee) to be considered. The ECI auditors require that refunds for all conference cancellations be processed after the conference so that the necessary back-up information (e.g., hotel list of those in-house) can be attached to the refund request and ECI can verify that the hotel has not charged a cancellation fee.

Cancellation fees:

  • Cancellations received more than 28 days prior to the conference start date are subject to a processing fee of 4% of the total fee, plus any direct expenses incurred by ECI.
  • Cancellations received 15 – 28 days prior to the conference start date are subject to a $250 cancellation fee plus any direct expenses incurred by ECI.
  • Cancellations received 8 – 14 days prior to the conference start date are subject to a $500 cancellation fee plus any direct expenses incurred by ECI.
  • No refunds will be issued for cancellations received less than 7 days prior to the conference start date.
  • No refunds will be issued due to inclement weather or travel disruptions/cancellations.

Registrations may be transferred without incurring any penalty or cancellation fee.

Denied or delayed visa

If a participant is forced to cancel due to a denied or delayed entry visa, ECI will issue a full refund if ECI has been notified of a potential visa issue at least four weeks prior to the conference start date.

Change of payment method

If an attendee who has already paid the conference fee with a credit card requests that the fee be refunded to that card so that it can be paid in a different manner (e.g., charged to an alternate credit card, or paid via check or bank transfer), a processing fee of 4% of the total fee amount will apply.

Disclaimer

It may be necessary for reasons beyond the control of ECI to alter the content and timing of the program or the identity of the speakers. In the unfortunate circumstance that an event is cancelled, ECI is not liable for any costs incurred by participants in connection with their attendance.

Smoking is prohibited at ECI conferences and conference functions.

Should you have specific questions regarding your registration, please contact Kathy Chan (Kathy@engconfintl.org).

Final Program

Please use This Link to view the final program.

Register Now!

Please use THIS LINK to register for this conference.

General Information About ECI

Engineering Conferences International (ECI) is a global engineering conferences program, originally established in 1962, that provides opportunities for the exploration of problems and issues of concern to engineers and scientists from many disciplines.

The format of the weeklong research conference provides morning and late afternoon or evening sessions in which major presentations are made. Available time is included during the afternoons for ad hoc meetings, informal discussions, and/or recreation. This format is designed to enhance rapport among participants and promote dialogue on the development of the meeting. We believe that the conferences have been instrumental in generating ideas and disseminating information to a greater extent than is possible through more conventional forums.

All participants are expected both to attend the entire conference and to contribute actively to the discussions. The recording/photographing of lectures and presentations is forbidden. As ECI conferences take place in an informal atmosphere, casual clothing is the usual attire.

Engineering Conferences International
32 Broadway, Suite 314, New York, NY 10004
T: 1-212-514-6760 F: 1-212-514-6030 E: info@engconfintl.org