Cell Culture Engineering XVI

An ECI Continuing Series

May 6-11, 2018
Saddlebrook Resort
Tampa, Florida, USA

18AC

About This Conference

Since 1988, the Cell Culture Engineering conferences have been held bi-annually and have developed into the leading global venue for the academic, industrial and regulatory communities for intensive interactions and debates to create solutions for improving human health and life by enabling rapid development and high quality manufacturing of an ever increasing number of viral vaccines, cell therapies, recombinant proteins and monoclonal antibodies. The 2018 conference, the 16th conference in this highly successful series, will be held at the beautiful Saddlebrook Resort in Tampa, Florida.  

This Cell Culture Engineering XVI conference will bring together about 350 selected participants from top academic, industrial and governmental groups from all over the world. We will celebrate the tradition of high quality and relevant accomplishments and debate future solutions in the area of animal cell culture science and engineering. Consistent with this excellent tradition, the scientific program will consist of invited and solicited oral presentations, extensive poster sessions, and workshops. Future updates to this website will detail the scientific program topics and call for oral and poster presentation abstract submissions.

Conference Organization

Chairs:

A. Robinson, PhD, Tulane University asr@tulane.edu
R. Venkat, PhD, MedImmune    rvv.cce16@gmail.com
E. Schaefer, ScD, J&J Janssen     gene@biochemeng.com

Conference Program

Please click on HERE to view the final program and posters.

 

 

 

 

 

 

 

 

Cell Culture Award

2018 Cell Culture Engineering Award Winner

William M. Miller                

Northwestern University

Bill has served the cell culture community for 30+ years through pioneering contributions, leadership, and training. Common themes in his research are (1) cell plasticity and the importance of the culture environment for modulating cell responses and (2) taking inspiration from the in vivo environment to develop more effective culture systems for cell-based therapies and tissue engineering. Bill’s most significant contributions include:

    • Biotherapeutic protein production: Bill’s PhD and independent research played a leading role in exploring environmental effects on cell growth, metabolism, and protein production, and helped provide the foundation for efficient biotherapeutic protein production. His papers on dilution rate, pH, and the levels of nutrients and metabolic byproducts have been highly cited and generated substantial interest in the biotechnology industry. Subsequent research elucidated the mechanisms responsible for cell inhibition by elevated pCO2.
    • Blood stem cells and megakaryocytes: Bill and collaborator Terry Papoutsakis were the first to show that low pO2 greatly enhanced stem and progenitor cell expansion, which has since been reported for a wide variety of stem cells. They developed mathematical models of the bone marrow O2 distribution and confirmed that stem and primitive progenitor cells likely reside at low pO2 in vivo. Bill’s team discovered that differentiation of megakaryocytic and erythroid cells, which must reach the bone marrow sinuses before they fully mature into non-motile platelets and red blood cells, is greatly enhanced at higher pO2and pH. These findings facilitated development of an efficient multi-stage culture process for megakaryocytic cells and platelets.
    • Bioreactors for blood cells and tissue engineering:  Bill and collaborators were among the first to develop bioreactors for blood stem and progenitor cells. They demonstrated the benefits of continuous perfusion for progenitor cell expansion, and showed that blood cells could be more effectively cultured in controlled, stirred-tank suspension bioreactors than in static flasks. More recently, Bill’s team used computational fluid dynamics to design a uniform-shear-rate microbioreactor to study platelet production, and developed well-characterized and controlled bioreactors to support renal cell expansion and differentiation in decellularized kidney scaffolds.
    • Mentorship and Service: Bill has directed Northwestern’s MS in Biotechnology Program for 10 years, directed the NIH Predoctoral Biotechnology Training Program since 2014, and co-directed a postdoctoral NIH training program at the intersection of engineering/data science and pediatrics since 2015. He has trained 39 PhD students, 7 postdoctoral fellows, and many MS and undergraduate students. His former trainees work and play leadership roles in a wide range of (bio)pharmaceutical and biotechnology companies.  He has also been an active member of the cell culture engineering community, having chaired CCE VII with Richard Schoenfeld in Santa Fe, NM and the Scale-up and Manufacturing of Cell-Based Therapies V conference with Tom Brieva.

    This prestigious award recognizes outstanding contributions to the field of Cell Culture and is given bi-annually at the Cell Culture Engineering conference. Former recipients: Wei-Shou Hu (2002), Eleftherios T. Papoutsakis (2004), W. Robert Arathoon (2006), Martin Fussenegger (2008), Michael J. Betenbaugh (2010), James M. Piret (2012), Jeffrey J. Chalmers (2014), and Konstantin B. Konstantinov (2016).

Martin Sinacore Award

2018 Martin Sinacore Young Investigator Award Winner

Amanda M. Lewis         

Bristol-Myers Squibb     

Amanda Lewis is a Senior Engineer in Manufacturing Sciences & Technology at Bristol-Myers Squibb, where she leads a team of scientists and engineers responsible for supporting new and existing commercial biologics processes.  She first joined BMS in 2013 in Biologics Development, and since then has held positions with increasing levels of responsibility.  In her time at BMS, she has developed expertise in ‘Omics tools for monitoring and characterization of biologics processes, and has led several studies using metabolomics and transcriptomics to increase understanding and control of product glycosylation.  She currently leads a cross-functional and cross-site initiative to integrate metabolomics testing into commercial programs to increase process understanding and robustness.  She also leads a white paper exercise to understand key relationships between critical quality attributes and process control from an end to end biologics design, development, and commercialization perspective.  She received her B.S. from MIT in 2008, and her PhD from the University of Texas at Austin in 2013, both in Chemical Engineering.

Amanda continues to engage in the broader scientific community.  She has co-authored 18 peer-reviewed publications, including 7 since joining BMS, and presented her work at 7 scientific conferences in the past 5 years.  She also serves as a guest editor for Current Opinion in Biotechnology’s Pharmaceutical Technology issue, and was recently invited to serve on the scientific advisory board for a PhD training program in Systems Biology.

Amanda has consistently demonstrated an interest in mentorship and STEM education.  Since 2011, she serves as an alumni interviewer for MIT, volunteering her free time to meet with high school students to answer questions about MIT and share her experience as an alumna.  She serves on the BMS University Relations team where she has championed a new initiative to partner with faculty across the country and build relationships with schools outside of the Northeast region.  She also developed and led a program called “BMS Women in ChemE Exploration Day”.  This annual event brings female chemical engineering undergraduate students from neighboring universities on-site for a day to learn about careers in BioPharma.  The program is intended to inspire more female engineering talent to consider long term careers in the Bioprocessing field.

Previous winners of this award are Colin Clarke (Dublin City University, Ireland),  Corinne Hoesli (McGill University, Canada), and Huong Le (Amgen).

Poster Awards

Poster Awards

General Information about ECI

Engineering Conferences International (ECI) is a global engineering conferences program, originally established in 1962, that provides opportunities for the exploration of problems and issues of concern to engineers and scientists from many disciplines.

The format of the weeklong research conference provides morning and late afternoon or evening sessions in which major presentations are made. Available time is included during the afternoons for ad hoc meetings, informal discussions, and/or recreation. This format is designed to enhance rapport among participants and promote dialogue on the development of the meeting. We believe that the conferences have been instrumental in generating ideas and disseminating information to a greater extent than is possible through more conventional forums.

All participants are expected both to attend the entire conference and to contribute actively to the discussions. The recording of lectures and presentations is forbidden. As ECI conferences take place in an informal atmosphere, casual clothing is the usual attire.

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