Pharmaceutical Engineering: At the Frontier of Drug Substance and Drug Product

An ECI Conference

May 3-7, 2020
Kloster Irsee
Irsee, Germany

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About This Conference

It is well known that the physical and chemical properties of the DS (API) have major impacts on the formulation and the Drug Product (DP) process. In any dosage form including solid, liquid and semi-solid, the Drug Substance (DS) or Active Pharmaceutical Ingredient (API) goes through a formulation process. This process to make the final drug product serves many purposes, but all with the goal of eventually delivering the active ingredient to the desired sites in the patients’ body in the most convenient way and to achieve optimal therapeutic effect.

For most small molecule drugs, the final step in an arduous synthetic sequence is usually the crystallization or precipitation of the DS. This serves as both an isolation as well as purification step. In addition, many particle engineering techniques have been advanced that can tailor the physical and chemical properties of the drug substance during the final step in order to facilitate the design and scaleup of a rugged and reproducible DP processes. From historical and regulatory viewpoints, the blurring of the DS/DP interface while having the potential to offer competitive advantages, there will be regulatory and cultural hurdles that need to be ameliorated. The impact of DS properties on DP performance and the DP processes have attracted wide interest in the industry. However, many engineering issues and mechanistic understanding concerning the DS, the formulation, and their interface still need to be developed and explored. This conference seeks to bring scientists, engineers and regulators working at this critical interface for mutual discussion of current results, future improvement and to identify any technical and regulatory needs that still exist. Participants attending this conference will significantly benefit from learning the innovations from the integration of DS (API) and the formulation of the drug product.

Program Themes

  • Role of particle engineering
  • Material science of API/DS and formulation -Impact on drug product performance and process scaleup
  • Pharmaceutical composite materials

Conference Organization

Chair:  Daniel S. Hsieh, Bristol-Myers Squibb (Retired)

Co-Chair:  San Kiang, Industrial Consultant

Organizing Committee

Deniz Erdemir, BMS, USA
Mauricio Futran, Janssen, USA
Junbo Gong, Tianjin University, China
Ren Guobin, East China University of Science and Technology, China
Soojin Kim, Hanmi Pharmaceutical Co., South Korea
Alfred Lee, Merck & Company Inc., USA
Allan Myerson, Massachusetts Institute of Technology, USA
Srividya Ramakrishnan, AstraZeneca, UK
Vidya Swaminathan, Europe
Bing-shiou Yang, Boehringer Ingelheim Pharmaceuticals, Inc., USA

Conference Venue

Kloster Irsee (Swabian Conference Centre at Irsee)  Nestling in the Alpine Foreland of the Allgäu and located only a few kilometers from walled town of Kaufbeuren, the former Benedictine monastery at Irsee – founded in the 12th century – now houses a modern conference center.  The magnificent Baroque church and the harmoniously designed four-winged monastery, surrounded by a well-kept park, away from major highways and yet easily reached, is particularly suitable for the conference.  The center offers a broad range of leisure activities including a bierstube in the cellar of the monastery and a game room with pool, table tennis and tabletop football.  There is also a bocce court and a sauna available for guests.  Nearby are many jogging trails, fitness trails, a tennis center, walking and hiking trails.  Across the court from the center is the Irsee brewery where conference attendees can enjoy beer directly from its source.  Note that there are no televisions in the bedrooms; however, one may be rented.

The nearest major airport is Franz-Josef Strauss Airport in Munich  and their web-link provides a great deal of useful information, including information for booking airport hotels.

A concert on the historic church organ is being arranged for early Sunday evening, May 3.  After the concert, conference participants are invited to go to the organ loft and informally meet the organist.

Kloster Irsee/Swabian Conference Center at Irsee is a good starting point for excursions and sightseeing tours to the Allgäu Mountains, to Lake Constance, to Austria and Switzerland. For those who plan to extend their stay, popular day-trips are to the Castles of Linderhof and Neuschwanstein (built by the Bavarian King Ludwig II), the scenic Tannheimer Valley and the Pfaffenwinkel with its famous Baroque churches (Wieskirche).

More information about Kloster Irsee can be found at this link.

Address:  Swabian Conference and Educational Centre, Kloster Irsee, Klosterring 4
D-87660 Irsee
Telephone: +49 (0)8341 906-00

Travel Information

Transportation to Conference Site  The Swabian Conference Center at Irsee rests in the Alpine Foreland of the Allgäu, yet is conveniently located near Munich and is easily reached by rail or road.  For those traveling from the airport by train, one can reach the Munich Main Station(Hauptbahnhof) in several ways: (1) by Lufthansa Airport Bus.  Departures are every typically 20 minutes for the 45 minutes trip.  Cost is approximately 10.5 € one- way and 17 € roundtrip . (2)  by Rapid Transit Train (“S-bahn” – either S1 or S8).  Departures are every 20 minutes for the 41 or 45-minute trip.  (3) by taxi.  The trip takes approximately 40-minutes and the price should be discussed with the driver.

From the Munich Main Station there are through trains to Kaufbeuren (about an hour ride).  In front of Kaufbeuren Station there is a taxi stand where you can hire a taxi to Irsee.

Conference Fees and Registration

Coming soon!

General Information about ECI

Engineering Conferences International (ECI) is a global engineering conferences program, originally established in 1962, that provides opportunities for the exploration of problems and issues of concern to engineers and scientists from many disciplines.

The format of the weeklong research conference provides morning and late afternoon or evening sessions in which major presentations are made. Available time is included during the afternoons for ad hoc meetings, informal discussions, and/or recreation. This format is designed to enhance rapport among participants and promote dialogue on the development of the meeting. We believe that the conferences have been instrumental in generating ideas and disseminating information to a greater extent than is possible through more conventional forums.

All participants are expected both to attend the entire conference and to contribute actively to the discussions. The recording/photographing of lectures and presentations is forbidden. As ECI conferences take place in an informal atmosphere, casual clothing is the usual attire.

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