METABOLIC ENGINEERING VII
The winner of the Jay Bailey Young Investigator Award (funded by the Promethegen Corporation) is
"The Antoniewicz lab for Metabolic Engineering and Systems Biology works on a wide range of topics in modern life sciences including Biofuels and Diabetes, where we apply techniques such as Metabolic Flux Analysis, Stable-isotope Labeling Experiments, e.g. 13C, 2H, 18O, and Tandem Mass Spectrometry to study cellular systems. The primary goal of our research efforts is to provide a comprehensive understanding of the function and regulation of complex biological processes that emerge through the interaction of genes, proteins, and metabolites at multiple metabolic and genetic regulatory levels. To achieve this, we develop novel experimental and computational tools to quantify cellular physiology and apply genome-wide models of cellular interactions to interpret the large sets of biological data generated from these technologies.
Our interests range from looking at model microbial systems, i.e. Saccharomyces cerevisiae and Escherichia coli, to investigations of mammalian cells such as hepatocytes, adipocytes and myocytes. Beyond large-scale identification of interactions and transcriptional control of network operations in isolated cells, we develop technologies for studying disease phenotypes at the whole organism level. Our results find applications in many areas including industrial biotechnology, e.g. metabolic engineering of microbial cells for the production of biofuels and biochemicals, and medicine, in particular, investigations of human metabolic disorders such as Type-2 Diabetes."