Program

BIOARTIFICAL ORGANS III
Tissue Sourcing, Immunoisolation and Clinical Trials

7-11 October 2000
Davos Congress Center/Hotel Cresta Sun
Davos, Switzerland

Conference Chair
David Hunkeler
Swiss Federal Institute of Technology

Conference Co-Chairs
Alan Cherrington
Vanderbilt University Medical Center
Ales Prokop
Vanderbilt University
Ray Rajotte
University of Alberta

United Engineering Foundation, Inc.
Three Park Avenue, 27th Floor
New York, NY 10016-5902
T: 1-212-591-7836 - F: 1-212-591-7441
engfnd@aol.com -- www.engfnd.org

Saturday, October 7, 2000

13:00 - 16:00 REGISTRATION (Lobby, Cresta Sun Hotel)

16:00 - 18:10 Session 1 : TISSUE SOURCING
Chairs: G. Korbutt and R. Gill

16:00 - 16:25 Ronald G. Gill (University of Colorado, USA) L-1
CELLULAR IMMUNITY TO IMMUNOISOLATED TRANSPLANTS

16:25 - 16:50 Gregory S. Korbutt (University of Alberta, Canada) L-2
IN VITRO EXPANSION OF ISLET ENDOCRINE CELLS

16:50 - 17:15 Ray V. Rajotte (University of Alberta, Canada) L-3
ADVANCES IN ISLET ISOLATION AND TRANSPLANTATION ñ
PAST, PRESENT, AND FUTURE

17:15 - 17:45 Don F. Cameron (University of South Florida, USA) L-4
TISSUE ENGINEERING OF SERTOLI-ENRICHED TISSUE CONSTRUCTS FOR TRANSPLANTATION THERAPY

17:45 - 18:10 Dawn R. Applegate (Advanced Tissue Sciences, La Jolla, CA, USA ) L-5
AN ENGINEERED HUMAN DERMAL TISSUE FOR APPLICATION TO WOUND REPAIR AND REVASCULARIZATION

19:00 - 20:30 OPENING DINNER Keynote Lecture
Yukihiko Nosè (Baylor College of Medicine, Houston, Texas, USA) L-6
HISTORICAL PERSPECTIVES OF BIOARTIFICIAL ORGANS: TISSUE SOURCING, IMMUNOISOLATION AND CLINICAL TRIAL

20:30 - 22:00 OPENING RECEPTION

Sunday, October 8, 2000 - Morning

07:30 - 08:30 BREAKFAST BUFFET

08:30 - 12:00 Session 2: ENCAPSULATION AND IMMUNOISOLATION
Chairs: A. Bartkowiak and D. Poncelet

08:30 - 08:55 Allan S. Hoffman (University of Washington, USA) L-7
HYDROGELS FOR BIOMEDICAL APPLICATIONS

08:55 - 09:20 Artur Bartkowiak (Technical University of Szczecin, Poland) L-8
OPTIMAL CONDITIONS OF BINARY POLYELECTROLYTE MICROCAPSULE FORMATION

09:20 - 09:45 Denis Poncelet (ENITIAA, Nantes, France) L-9
PRODUCTION OF ALGINATE BEADS BY EMULSIFICATION-INTERNAL GELATION

09:45 - 10:10 Josef P. Magyar (Institute of Cell Biology, ETHZ, Switzerland) L-10
MASS PRODUCTION OF EMBRYONIC BODIES IN MICROBEADS AND THEIR USE AS A MODEL SYSTEM FOR THE ENCAPSULATION OF PANCREATIC ISLETS

10:10 - 10:45 COFFEE BREAK

10:45 - 11:10 Clark K. Colton (M.I.T., Cambridge, USA) L-11
ADVANCES IN BIOARTIFICIAL PANCREAS DEVICES

11:10 - 11:35 Ioannis Constantinidis (Emory University, Atlanta, USA) L-12
EFFECTS OF ALGINATE COMPOSITION ON THE PROPERTIES OF ENCAPSULATED CELLS

11:35 - 12:00 Ales Prokop (Vanderbilt University, USA) L-13
BIOARTIFICIAL ORGANS IN THE 21ST CENTURY: NANOBIOLOGICAL DEVICES

Sunday, October 8, 2000 - Afternoon

12:30 - 13:30 LUNCH

13:30 - 15:00 FREE TIME FOR AD HOC DISCUSSIONS/RECREATION

15:00 - 17:00 POSTER SESSION #1 (coffee served 15:00 - 16:00)

17:30 - 19:00 Session 3: BIOMATERIAL PURIFICATION AND COMPATIBILITY
Chairs: U. Zimmermann and D. Hunkeler

17:30 - 18:00 Gudmund Skjak-Braek (University of Trondheim, Norway) L-14
ALGINATE AS IMMOBILSATION MATERIALS FOR CELLS

18:00 - 18:30 Ulrich Zimmermann (University of W¸rzburg, Germany) L-15
ALGINATE PURIFICATION AND MICROENCAPSULATION

18:30 - 19:00 Christine Wandrey (Swiss Federal Institute of Technology, Lausanne, Switzerland) L-16
PURIFICATION OF POLYMERIC BIOMATERIALS

19:30 - 21:00 DINNER

21:00 - 22:00 RECEPTION

Monday, October 9, 2000 - Morning

08:00 - 08:30 BREAKFAST BUFFET

08:30 - 14h30 EXCURSION (BOX LUNCH PROVIDED)

15:00 - 15:30 COFFEE BREAK

Monday, October 9, 2000 - Afternoon

15:30 - 18:25 Session 4: ISLET AND BIOARTIFICIAL PANCREAS
Chairs : R. Calafiore and R. Rajotte

15:30 - 15:55 Anthony M. Sun (University of Toronto, Canada) L-17
RECENT ADVANCES IN THE DEVELOPMENT OF THE ARTIFICIAL PANCREAS AND OTHER ARTIFICIAL ORGANS

15:55 - 16:20 Riccardo Calafiore (University of Perugia, Italy) L-18
CO-MICROENCAPSULATION OF ISLETS WITH CELLULAR NURSING SYSTEMS FOR TRANSPLANTATION IN DIABETES MELLITUS

16:20 - 16:45 Taylor D. Wang (Vanderbilt University, USA) L-19
ADVANCES IN MICROENCAPSULATION TECHNOLOGY AND MATERIALS

16:45 - 17:10 Shinji Sakai (Graduate School of Engineering, Kyushu, Japan) L-20
NEWLY DEVELOPED AMINOPROPYL-SILICATE IMMUNOISOLATION MEMBRANE TOWARD MICROCAPSULE-SHAPED BIOARTIFICIAL PANCREAS

17:10 - 17:35 Derek W.R. Gray (John Radcliffe Hospital, Oxford, United Kingdom) L-21
PANCREATIC ISLET TRANSPLANTATION -- OPEN ISSUES

17:35 - 18:00. Nicolas Lembert (University of T¸bingen, Germany) L-22
IN VITRO TEST OF NEW BIOMATERIALS FOR THE DEVELOPMENT OF A BIOARTIFICIAL PANCREAS

18:00 - 18:25 Bernard Thorens (University of Lausanne, Switzerland) L-23
ENGINEERING TOLERANCE INTO TRANSPLANTED _ CELL LINES

19:30 - 21:00 DINNER

21:00 - 22:00 RECEPTION

Tuesday, October 10, 2000 - Morning

07:30 - 08:30 BREAKFAST BUFFET

08:30 - 12:00 Session 5: BIOARTIFICIAL LIVER AND KIDNEY: BIOLOGY,
DEVELOPMENT AND CLINICAL APPLICATION
Chairs : L. Reid and J.F. Patzer

08:30 - 09:00 David Humes (University of Michigan, USA) L-24
BIOARTIFICIAL KIDNEY

09 :00 - 09:30 Beatrice Desvergne (University of Lausanne, Switzerland) L-25
ENCAPSULATION OF HEPATOCYTES - IN VIVO AND IN VITRO PERSPECTIVES

09:30 - 10.00 Hiroo Iwata (Kyoto University, Japan) L-26
QUANTITATIVE EVALUATION OF METABOLIC FUNCTIONS OF BIOARTIFICIAL LIVER

10:00 - 10:30 COFFEE BREAK

10:30 - 11:00 Jörg Gerlach (Humbold University, Berlin, Germany) L-27
ACUTE LIVER FAILURE AND DEVELOPMENT OF LIVER SUPPORT THERAPY

11:00 - 11:30 John F. Patzer II (University of Pittsburgh, USA) L-28
ADVANCES IN BIOARTIFICIAL LIVER SUPPORT SYSTEMS

11:30 ñ 12h00 Yuichiro Ueda, Kyoto University, Japan L-29
COLD PRESERVATION OF BIOARTIFICIAL LIVER Tuesday, October 10, 2000 - Afternoon

12:30 - 13:30 Lunch

13:30 - 15:00 FREE TIME FOR AD HOC DISCUSSIONS/RECREATION

15:00 - 17:00 POSTER SESSION #2 (Coffee served 15 :00 - 16 :00)

17:30 - 19:00 CONCURRENT PANEL SESSIONS (choice of one)
Panel Session 1 (Facilitator: Colton)

BIOCOMPATIBILITY AND BIOARTIFICIAL ORGAN FUNCTION
Panelists:
Yukihiko Nosè (Baylor College of Medicine, USA)
Jeffrey O. Hollinger (Oregon Health Science University, Portland, USA)
Ronald G. Gill (University of Colorado, Denver, USA)

Panel Session 2 (Facilitator: Hunkeler)
TISSUE ISOLATION AND BIO+AO COMMERCIALIZATION
Panelists:
Kermit Borland, Cell & Tissue Bio. Cambridge USA
Ray V. Rajotte, University of Alberta, Canada
Dawn R. Applegate, Advanced Tissue Sciences, USA

19:30 AWARD DINNER

DINNER TALK
Alan Cherrington (Vanderbilt Uni., School of Medicine, Nashville, USA)
NEW ADVANCES IN THE TREATMENT OF DIABETES L-30

Wednesday, October 11, 2000 - Morning

07:30 - 08:30 BREAKFAST BUFFET

08:30 - 12:00 Session 6: CLINICAL TRIALS: BLOOD SUBSTITUTES AND ENDOCRINOLOGY
Chairs: T.M. Chang and Ph. Morel

08:30 - 09:00 Thomas M. Chang (McGill University, Montreal, Canada) L-31/32
RED BLOOD CELL SUBSTITUTES AND ARTIFICIAL CELLS FOR ORAL THERAPY IN UREMIA

09:00 - 09:30 Patrick Aebischer (University Hospital of Lausanne, Switzerland)
WHAT HAVE WE LEARNED FROM CLINICAL TRIALS REGARDING THE REQUIREMENT FOR CELL ENCAPSULATION ?

09:30 - 10:00 Reinout Van Schilfgaarde (University of Groningen, Netherlands) L-33
ALGINATE MICROCAPSULES AS A BIOARTIFICIAL PANCREAS

10:00 - 10:30 COFFEE BREAK

10:30 - 11:00 Philippe Morel (University Hospital of Geneva, Switzerland)
CLINICAL RESULTS IN ISLET AUTO- AND ALLOTRANSPLANTATION

11:00 - 11:30 Bettina Knorr (Bavarian Nordic, Germany) L-34
DEVELOPMENT OF CAPCELL BASED ON CELLULOSE SULFATE AND PDADMAC CONTAINING MAMMALIAN CELLS FOR PANCREAS TUMOUR THERAPY

11:30 - 12:00 General Discussion Wednesday, October 11, 2000 - Afternoon

12:00 - 13:30 LUNCH

13:30 - 17:00 FREE TIME FOR AD HOC DISCUSSIONS AND/OR RECREATION

17:00 - 17:30 COFFEE BREAK

17:30 - 19:00 Session 7 : TISSUE ENGINEERING
Chairs: I.V. Yannas and B.L. Strand

17h30 - 18h00 Michael Dornish, Pronova Biomedical, Oslo, Norway L-35
STANDARDS AND GUIDELINES FOR BIOPOLYMERS IN TISSUE ENGINEERED MEDICAL PRODUCTS: ASTM ALGINATE AND CHITOSAN STANDARD GUIDES

18h00 - 18h30 Ioannis V. Yannas (M.I.T, Cambridge, USA) L-36
SYNTHESIS OF TISSUES AND ORGANS : IN VITRO OR IN VIVO

18:30 - 19h00 Lola Reid (University of North Carolina, USA) L-37
BIOLOGICAL ISSUES RELEVANT TO THE ESTABLISHMENT OF BIOARTIFICIAL ORGANS

19:30 - 21:00 DINNER

Thursday, October 12, 2000 - Morning

07:30 - 08:30 BREAKFAST BUFFET

08:30 - 10:30 Session 8: Biotech Funding and Success Stories

08:30 - 09:00 Michael Rheinnecker (TechnoStart GmbH, Ludwigsburg, Germany) L-38
VENTURE CAPITAL FOR START-UP COMPANIES

09:00 - 09:30 Jean Pierre Rosat (Cytion S.A., Epalinges, Switzerland)
CYTION: NEW TOOLS FOR DRUG DISCOVERY

09:30 - 10:00 COFFEE BREAK

10:00 - 10:30 Hermann Roduner (Director of Credit Suisse First Boston, Zurich)
IPO: THE FUTURE FOR SWISS START-UPS.

10:30 - 11h00 Andrew Galazka (Senior Vice President, Scientific Affaires, Ares Serono, Geneva)
SERONO - EUROPE'S PREMIER BIOTECH COMPANY

11:00 - 12:00 Discussion
Departure or BIOTECH MARKET

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Poster Presentations

(Titles in alphabetical order)

1. A FINITE ELEMENTS APPROACH TO MODEL GLUCOSE, INSULIN AND OXYGEN MASS TRANSFER IN A HOLLOW FIBER BIOARTIFICIAL PANCREAS
Jean-Luc Dulong, Universitè de Technologie de Compiëgne, France

2. AN APPROACH TO CONSTRUCT 3-DIMENSIONAL (3-D) TISSUE
In Kap Ko, Institute for Frontier Medical Sciences, Kyoto University, Japan

3. APPROACHES TO MICROENCAPSULATED FORM OF LIVE MEASLES VACCINE
E.Netcheva, State Research Center of Biotechnology and Virology VECTOR, Koltsova, Russia

4. CELL TRANSPLANTATION AS A CORRECTIVE METHOD FOR SOME ENDOCRINE DISEASES
O.Galibin, St.Petersburg State Medical University, Russia

5. CELLULAR OVERGROWTH ON MICROCAPSULES TRANSPLANTED TO INOS KNOCKOUT MICE.
Aileen King, Uppsala University, Sweden

6. CONSTRUCTION OF AMMONIA-METABOLIZING CELL LINES AND ITS APPLICATION TO HYBRID BIOARTIFICIAL LIVER SUPPORT SYSTEM
Ken-ichi Suga, Dept. of Biotech., Grad.Sch. of Eng., Osaka University, Japan

7. DEVELOPMENT OF AN IN VITRO MODEL FOR ISLET CELL NEOGENESIS.
Tanya M. Binette, Surgical-Medical Research Institute, Department of Surgery, Alberta, Canada

8. EFFECTS OF CAPSULE SIZE REDUCTION ON MECHANICAL STABILITY, DIFFUSION PROPERTIES AND IN VITRO CELLULAR ACTIVITIES
Laurence Canaple, Laboratory of Polyelectrolytes and BioMacromolecules, Department of Chemistry, Swiss Federal Institute of Technology, Lausanne, Switzerland

9. ELECTRIC STIMULATED REGULATION OF INTRACELLULAR GENE EXPRESSION FOR TISSUE ENGINEERING
Yasuko Yanagida, Tokyo Institute of Technology, Japan

10. EVALUATING THE PERFORMANCE OF A HYBRID ARTIFICIAL LIVER SUPPORT SYSTEM WITH RECOVERABLE HEPATIC FAILURE RAT MODEL
Hiroyuki IJIMA, Dept. of Chemical Engineering, Faculty of Engineering, Kyushu University, Japan

11. EVALUATION OF C3A HEPATOCYTES VIABILITY AND FUNCTIONALITY IN ALGINATE BEADS
Bertrand David, Universitè de Technologie de Compiëgne, France

12. GENE EXPRESSION PATTERNS DURING HEPATOCYTE SELF-ASSEMBLY INTO A TISSUE-LIKE STRUCTURE
Wei-Shou Hu, Dept. Chemical Engineering and Materials Science, University of Minnesota, USA

13. HUMAN HEPTIC PROGENITOR CELLS
Nicholas Moss, UNC School of Medicine, Chapel Hill, North Carolina, USA

14. INVESTIGATION OF BIOARTIFICIAL PANCREAS ENERGETICS THROUGH 13C NMR
Nicholas E. Simpson, Emory University, Atlanta, USA

15. IN-VIVO GENERATION OF A 3-DIMENSIONAL VASCULAR SCAFFOLD AS A BASIS ON WHICH TO BIO-ENGINEER ORGANS
Aurora Messina, Bernard O'Brien Institute of Microsurgery, Melbourn, Australia

16. MECHANICAL PROPERTIES OF MULTICOMPONENT MICROCAPSULES
Annemie Rehor, Swiss Federal Institute of Technology Lausanne, Switzerland

17. NMR IN CELLULAR AND TISSUE ENGINEERING
Klearchos K. Papas, Department of Chemical Engineering, Massachusetts Institute of Technology, USA

18. NON-INVASIVE MONITORING OF A BIOARTIFICIAL PANCREAS.
Ioannis Constantinidis, Emory University, Atlanta, USA

19. NOVEL THIN SHEET BIOARTIFICIAL PANCREAS
Scott King, Islet Sheet Medical , San Francisco, USA

20. POROUS BIODEGRADABLE AND BIOCOMPATIBLE BEADS FOR TISSUE ENGINEERING
Arron S. L. Xu, Department of Cell & Molecular Physiology, UNC-CH, Chapel Hill, North Carolina, USA

21. PRODUCTION AND CHARACTERIZATION OF PECTIN MICROSPHERES
Nastruzzi Claudio, Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy

22. PRODUCTION OF LIPOSPHERES AS CARRIERS FOR BIOACTIVE COMPOUNDS
Nastruzzi Claudio, Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy

23. SODIUM CELLULOSE SULFATE IN POLYELECTROLYTE COMPLEXES - PROTECTIVE MATERIAL FOR ENGINEERED TISSUE UND CELL CULTURES APPLICATION: MEMBRANE SYSTEM FOR IN-VIVO PROTECTION OF HUMAN CARTILAGE IMPLANTS
Gerd Grasnick, Research Group "Polyelectrolyte Complexes" , University of Potsdam, Teltow, Germany

24. THE METHOD OF PEG-GRAFTING ONTO THE PANCREATIC ISLET MEMBRANE FOR IMMUNOPROTECTION IN ISLET TRANSPLANTATION
Dong Yun Lee, Dept. of Materials Science and Engineering, Kwangju Institute of Science and Technology (K-JIST), Japan

25. TISSUE ENGINEERING OF HUMAN LIVER IN A COAXIAL HOLLOW FIBER BIOREACTOR
Jeffrey M. Macdonald,, Departments of Biomedical Engineering, University of North Carolina, Chapel Hill, 27599, USA

26. TOWARDS VASCULARIZED BIOARTIFICIAL PANCREAS (VBAP): LONGEVITY OF THE NEOVASCULAR BED
Ales Prokop, Chemical Engineering and Pathology Departments, Vanderbilt University, Nashville, USA

27. TRANSPLANTATION OF ALGINATE MICROCAPSULES WITH PROLIFERATING CELLS IN MICE: CAPSULAR OVERGROWTH AND SURVIVAL OF ENCAPSULATED CELLS IN ALLO- AND XENO GRAFT MODELLS
Anne Mari Rokstad, Institute of Cancer Research and Molecular Biology, Norway

28. VISUALIZING ALGINATE-PLL-ALGINATE CAPSULES AND IDENTIFICATION OF CELLS IN THE FIBROTIC REACTION AGAINST IMPLANTED CAPSULES BY LASER SCANNING CONFOCAL MICROSCOPY
Berit L. Strand, Department of Biotechnology, Norwegian University of Science and Technology , Norway

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