Metabolic Engineering IV - Session II Posters

1. Analyzing the metabolome of Trichoderma reesei
Hendrik Meerman, Genencor International, USA
M.J. van der Werf, TNO Nutrition and Food Research, The Netherlands

2. High-throughput metabolic flux profiling in batch culture
Eliane Fischer, Uwe Sauer, Institute of Biotechnology, ETH Zürich, Switzerland

3. Methodological innovations in 13C-labeling based metabolic network and flux analysis applied to P. Chrysogenum and S. Cerevisiae
Wouter A. van Winden, Jan C. van Dam, Walter M. van Gulik, Peter J.T. Verheijen, Joseph J. Heijnen, Kluyver Laboratory for Biotechnology, Delft University of Technology, The Netherlands

4. Time-lagged statistical analysis for improved metabolic engineering
Kenneth J. Kauffman, Jeremy S. Edwards, University of Delaware, USA

5. Uncertainties and measurement errors in 13C metabolic flux analysis
Wolfgang Wiechert, Aljoscha Wahl, Katharina Nöh, University of Siegen, Germany

6. Applied system biology; process development in bioreactors using statistical designs. impact of dissolved CO2 on performance at 2Ll, 400L and 2000L scales
Neslihan DelaCruz, Gordon Crupi, Tina Etcheverry, Genentech, Inc., USA

7. Elementary mode analysis to analyze flux distributions in lactobacillus rhamnosus on multiple substrates
David A Fell, M. G. Poolman, Oxford Brookes University, UK
V. K. Venkatesh, B. D. Jyoti, IIT Bombay, India

8. Metabolic engineering analysis of disease: Hepatic metabolism
Francois Berthiaume, Shriners Hospital for Children, USA
Kyongbum Lee, Gregory N. Stephanopoulos, Massachusetts Institute of Technology, USA
Scott Banta, Martin L. Yarmush, Massachusetts General Hospital, USA

9. Application of linlog kinetics in metabolic modeling
J.J. Heijnen, M.T.A.P. Kresnowati, F.O. Aboka, W.M. van Gulik, Delft University of Technology, The Netherlands
D. Visser, Purac Biochem BV, The Netherlands

10. Transcriptome and proteome analysis of Saccharomyces cerevisiae metabolic response to glucose and ethanol as carbon sources
Pascale Daran-Lapujade, Mariela Serrano-Davalos, Marijke A.H. Luttik, Walter van Gulik, Jack T. Pronk, Technical University of Delft, The Netherlands

11. Use of a pathway distance metric through linear programming for the analysis of metabolic networks
Evangelos Simeonidis, Stuart C.G. Rison, I. David L. Bogle, Lazaros G. Papageorgiou, University College London, UK
Janet M. Thornton, European Bioinformatics Institute, Wellcome Trust Genome Campus, UK

12. Metabolic flux analysis of adenovirus production in perfusion cultures of 293 cells
Olivier Henry, Amine Kamen, NRC Biotechnology Research Institute, Canada
Michel Perrier, Ecole Polytechnique de Montreal, Canada

13. Searching the metabolome: Toward in silico metabolic pathway engineering
Daniel McShan, Imran Shah, University of Colorado Health Science Center, USA

14. Reconstruction of the dynamic oxygen uptake rate and carbon dioxide evolution rate during a pulse experiment
L. Wu, H.J. Bloemen, W.M. van Gulik, M.H.G. Verhaegen, J.J. Heijnen, Delft University of Technology, Kluyver Laboratory, The Netherlands

15. ScrumPy - An object oriented software package for metabolic modelling
Mark G. Poolman, David A. Fell, Oxford Brookes University, UK

16. Minimal perturbation analysis of metabolic gene knockouts
Daniel Segre, Dennis Vitkup, George M. Church, Harvard Medical School, USA

17. Analysis of global structure and evolution of genome-based metabolic networks
Jibin Sun, An-Ping Zeng, Hongwu Ma, German Research Center for Biotechnology, Germany

18. A global optimization approach for metabolic flux analysis
Carlos Arturo Martinez Riascos, Andreas Karoly Gombert, Jose Mauricio Pinto, University of Sao Paulo, Brazil

19. Effect of culture conditions on growth, productivity, and proteome of CHO cells expressing recombinant proteins
Soo Young Stanford Lee, Matthias Brand, Keli Ou, Susan Lee Teck Lian, Biopharmaceutical Manufacturing Technology Centre (BMTC), Singapore
Jaeseung Yoon, Kyung Hee University, Korea

20. Antithrombotic protection of the vascular wall by modified antioxidant enzymes
Alexander V. Maksimenko, Vladimir.L.Golubykh, Elena.G.Tischenko, Russian Cardiology Research Center, Russia

21. Application of metabolic engineering and multivariate analyses to optimize hepatic function
Christina Chan, Michigan State University, USA
Daehee Hwang, George Stephanopoulos, Gregory Stephanopoulos, MIT, USA
Martin L. Yarmush, Harvard Medical School/Mass General Hospital, USA

22. Integrating fluxes, metabolite concentrations and enzyme activities for the predictive modeling of metabolic regulation
Eric von Lieres, Wolfgang Wiechert, University of Siegen, Germany
Sören Petersen, Metabolic Explorer GmbH, Germany

23. Metabolic Activity Profiling: Merging dynamic flux analysis and metabolomics
Sören Petersen, Albert A. de Graaf, Metabolic Explorer GmbH, Germany

24. Inferring gene regulatory networks from DNA microarray time series data
Costas D. Maranas, Anshuman Gupta, Pennsylvania State University, USA

25. C463A, A spontaneous mutant derived from Sp2/0, is capable of growth in chemically defined media and high IgG expression
ChiChang Lee, Celia Ly, Gill Carton, Xiaomei Shi, Edward Savino, Tina Lee, Gordon Moore, Fred Bader, Centocor, Johnson & Johnson, USA

26. Roles of mannitol and glycerol in Aspergillus stress response
George Ruijter, Leiden University Medical Centre, Netherlands
Maarten Bax, Simon Flitter, Ronald de Vries, Utrecht University, Netherlands
Jaap Visser, FGT Consultancy, Netherlands

27. Osmoregulation of the hexose-phosphate recycling in Sinorhizobium meliloti
Isabelle Gosselin, Inés Garbayo, Jean-Noël Barbotin, Laboratoire de Génie Cellulaire, Université de Picardie-Jules Verne, France
Jean-Charles Portais, Centre de Bioingénierie Gilbert Durand, France

28. Analysis on kinetic sugar metabolism of suspension plant cells pre-cultured under various conditions by mid-infrared spectroscopy
Atsushi Hashimoto, Akiko Kurokawa, Kenichi Nakanishi, Takaharu Kameoka, Mie University, Japan

29. Development of quantification system of ionic dissociative materials in glycolytic pathway using an FT-IR/ATR method
Tao Pan, Kenichi Nakanishi, Atsushi Hashimoto, Takaharu Kameoka, Mie University, Japan

30. Metabolic modelling as a tool for the study of the metabolism of neurotransmitter glutamate in rat cerebral cells
Aristotle Chatziioannou, F.N. Kolisis, National Technical University of Athens, Greece
G. Palaiologos, University of Athens, Greece

31. Structure and dynamics of the TGF-beta signaling network
Julio Saez-Rodriguez, Andreas Politzer, Knut Behrendt, Matthias Reuss, Klaus Mauch, Institute of Biochemical Engineering, Germany

32. Modular visualization and analysis of large-scale cellular networks
Matthias Reuss, Henning Schladebach, Institute of Biochemical Engineering, Germany
Knut Behrendt, Michael Dauner, Klaus Mauch, INSILICO Biotechnology GmbH, Germany

33. A nutritional and metabolic model describing hairy roots growth and secondary metabolites production
Mario Jolicoeur, Mathieu Leduc, Cyril Tikhomiroff, Ecole Polytechnique de Montreal, Canada

34. Integration of transcriptome data into genome-scale metabolic models
Mats Åkesson, Jochen Förster, Christoffer Bro, Steen Lund Westergaard, Jens Nielsen, BioCentrum-DTU, Denmark

35. Genetic strategies directed to protect hybridoma cultures from apoptosis
Joaquim Vives, Sandra Juanola, Jordi J. Cairó, Francesc Godia, Dep. d'Enginyeria Química, ETSE, UAB, Spain
Eva Prats, L. Cornudella, Dep. de Biologia Molecular i Cellular, IBMB, CSIC, Spain

36. Quantification of metabolic fluxes in developing soybean (Glycine max) embryos
Ganesh Sriram, D. Bruce Fulton, Mark E. Westgate, Martin H. Spalding, Jacqueline V. Shanks, Iowa State University, USA

37. Combining NMR study and genomic analysis to understand glucose metabolism of Propionibacterium freudenreichii subsp. shermanii
Catherine Deborde, Guillaume Meurice, Daniel Jacob, Diliana Dimova, INRA-Laboratoire de Recherche de Technologie Laitière, France
Patrick Boyaval, Rhodia Food Dangé Laboratories, France

38. Metabolic fluxes in riboflavin-producing bacillus subtilis during transient states
Nicola Zamboni, Eliane Fischer, Uwe Sauer, ETH Zürich, Switzerland
Hans-Peter Hohmann, Roche Vitamins Inc., Switzerland

39. Proteomic analysis of metabolic changes in fed-batch CHO cell cultures
Deborah E. Pascoe, David Arnott, Dana C. Andersen, Genentech, Inc., USA
William M. Miller, E. Terry Papoutsakis, Northwestern University, USA

40. MEtabolic TRer ANalysis (METRAN): Software for metabolic flux analysis and isotopomer spectral analysis
Maciek R. Antoniewicz, Gregory Stephanopoulos, Massachsetts Institute of Technology, USA
Joanne K. Kelleher, George Washington University, USA

41. Using mathematical modelling for reconstruction of regulatory pathways
Mikkel Nordkvist, Morten Skov Hansen, Jens Nielsen, John Villadsen, Center for Process Biotechnology, Technical University of Denmark, Denmark

42. Investigation of network topology and quantification of fluxes in central carbon metabolism of Aspergilli under different conditions of glucose repression
Helga David, Mats Åkesson, Jens Nielsen, BioCentrum-DTU, Technical University of Denmark, Denmark

43. Eukaryotic metabolism investigated through yeast model by multiple substrate feeding strategy and labelling experiments
Kashif Sheikh, Lars K. Nielsen, University of Queensland, Australia

44. Characterization of differential protein expression associated with adaptation of NSO transfected cell line to protein-free medium
Kathya R. de La Luz Hernández, Yamilet Rabasa, Svieta Victores, Adolfo Castillo Vitlloch, Lila Castellanos, Center of Molecular Immunology, Cuba

45. Study of apoptosis induction mechanisms in NSO recombinant myeloma cell line as selection criteria for inverse cell engineering
Adolfo Castillo Vitlloch, Svieta Víctores, Evelyn Faife, Kathya R. de la Luz Hernández, Center of Molecular Immunology, Cuba

46. Pathway reconstruction in Saccharomyces cerevisiae: Using DNA array data from deletion mutants
Steen Lund Westergaard, Christoffer Bro, Steen Knudsen, Lisbeth Olsson, Technical University of Denmark, Denmark

47. Brown-adipocyte differentiation: A metabolic-engineering challenge to quantify the roles of genes, hormones, metabolites, and signaling cascades
Hyuntae Yoo, Joanne K. Kelleher, Gregory Stephanopoulos, Massachusetts Institute of Technology, USA

48. Modeling and analysis of large-scale translation networks
Vassily Hatzimanikatis, Amit Mehra, Northwestern University, USA

49. Metabolic engineering of Escherichia coli for the production of polyhydroxyalkanoates consisting of short-chain-length and medium-chain-length monomers
Jong Hyun Choi, Jong Pil Park, Si Jae Park, Sang Yup Lee, Korea Advanced Institute of Science and Technology, Korea

50. Expression of pyruvate carboyxlase improves recombinant protein production in Escherichia coli
Mark A. Eiteman, Elliot Altman, John C. March, University of Georgia, USA

51. Design of precursor supply from central carbon metabolism in a wildtype strain and in an overproducer
J. W. Schmid, K. Mauch, M. Reuss, Institute of Biochemical Engineering, Germany
A. Kremling, Max-Planck-Institut für Dynamik komplexer technischer Systeme, Germany

52. Reducing the complexity of kinetic models of metabolic networks
Ziomara P. Gerdtzen, Prodromos Daoutidis, Wei-Shou Hu, University of Minnesota, USA

53. Metabolic engineering of Escherichia coli for the production of medium-chain-length polyhydroxyalkanoates
Seung Hwan Lee, Si Jae Park, Jong Pil Park, Sang Yup Lee, Korea Advanced Institute of Science and Technology, Korea

54. Elucidation of the metabolic fate of glucose in Trichoderma reesei using EST analysis and cDNA microarray: A step toward metabolic engineering of the regulatory networks for anaerobic metabolism of glucose
Hamza El-Dorry, Felipe Chambergo, Ynés Valencia Morante, University of São Paulo, Brazil

55. Comparative network analysis of a strain genealogy of lysine producing corynebacteria - tracing back the history of strain optimization for future targeted design
Elmar Heinzle, Christoph Wittmann, Biochemical Engineering, Saarland University, Germany

56. Metabolic engineering of cell cycle and apoptosis genes
Mohamed Al-Rubeai, Shikiko Watanabe, Neysi Ibarra, Jingxiu Bi, John Shuttleworth, University of Birmingham, UK

57. Integration of metabolic flux distributions with gene and protein expressions
Kazuyuki Shimizu, Yang Chen, Kyushu Institute of Technology, Japan
Hua Qiang, Jiao Zhao, Keio University, Japan

58. Steady state simulation of signal transduction systems
K. V. Venkatesh, Vivek Mutalik, Indian Institute of Technology, India
Aditya P Singh, Jeremy Edwards, University of Delaware, USA

59. A phenotype phase plane analysis of the synthesis of recombinant SOD in yeast
B.A. Andrews, J.A. Asenjo, C. Basulto, University of Chile, Chile
R. Gonzalez, Iowa State University, USA

60. Metabolic engineering of Catharanthus roseus hairy roots using an inducible promoter
Ka-Yiu San, Erik Hughes, Seung-Beom Hong, Sue Gibson, Rice University, USA
Jacqueline V. Shanks, Iowa State University, USA

61. Validation of a predictive Escherichia coli metabolic model
Jason R. DiTonno, Jeremy Edwards, University of Delaware, USA

62. Volatile anesthetic Halothane causes cell damage
Tanya Topouzova, Vesselina Moskova, Elena Stephanova, Sofia University, Bulgaria
Paula Daza, Seville University, Spain

63. Quantitative and qualitative analysis of phospholipids released in the culture medium from A549 human lung carcinoma cell line
Ralitza Valtcheva, Albena Jordanova, Elena Stephanova, Zdravko Lalchev, Sofia University, Bulgaria

64. Cofactor engineering of Acetyl-CoA and its subsequent effect on metabolic flux redistribution and the production of ester in E. coli
Ka-Yiu San, George N. Bennett, Ravi V. Vadali, Rice University, USA

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