PRELIMINARY PROGRAM

BIOARTIFICIAL ORGANS II:
Technology, Medicine and Materials

18 - 22 July 1998
Greenwood Inn and Conference Center
511 Bow Valley Trail
Canmore (Banff), Alberta, Canada

Conference Chair:
Professor David Hunkeler
Swiss Federal Institute of Technology

Conference Co-Chairs:
Professor Michael Sefton,
University of Toronto

Professor Ray Rajotte
University of Alberta

Professor Alan Cherrington
Vanderbilt University

Professor Ales Prokop
Vanderbilt University

Engineering Foundation
345 East 47th Street
New York, NY 10017
1-212-705-7836 - Fax: 1-212-705-7441
engfnd@aol.com -- www.engfnd.org

Organizing Committee

Patrick Aebischer
CHUV/University of Lausanne, Lausanne, Switzerland
Clark Colton
Massachusetts Institute of Technology, Cambridge, MA, USA
Eleni Kousvelari
National Institutes of Health, Bethesda, MD, USA
Robert Lanza
BioHybrid Technologies, Shrewsbury, MA, USA
Alan Laskin
Engineering Foundation, New York, NY USA
Hiroo Iwata
National Cardiovascular Institute, Osaka, Japan
Gail Naughton
Advanced Tissue Science, La Jolla, CA, USA
Lola Reid
University of North Caroline, Chapel Hill, NC, USA
Athanassios Sambanis
Georgia Institute of Technology, Atlanta, GA, USA
David Scharp
Neocrin, Irvine, CA, USA
Tobias Zekorn
Justus-Liebig University, Giessen, Germany

Post Conference Report

Poster Presentations

Saturday, July 18, 1998

15:00 - 17:30 Registration

17:30 - 19:00 Opening Dinner

Introductory Remarks
Alan Cherrington

Dinner Talk
Dr. Fritz Bach
Harvard University, Cambridge, Massachusetts, USA
"Balancing Individual Benefit versus Collective Risk"

19:00 (1) Plenary Session I: Novel Materials and Clinical Applications
Co-Chairs: Lola Reid and Ulrike Siebers

T.M.S. Chang
McGill University, Montreal, CANADA
"Artificial Cells, Immobilization and Encapsulation"

Murray A. Potter and Patricia Chang et al.
McMaster University, Hamilton, Ontario, Canada
"Suppression of Immunological Response Against A Transgene Product Delivered from Microencapsulated Cells"

Ray V. Rajotte
Surgical-Medical Research Institute, University of Alberta, CANADA
"Islet Cryopreservation"

Ph. Morel
University of Geneva Hospital, SWITZERLAND
"Clinical Islet Transplantation"

Patrick Aebischer
CHUV, Lausanne SWITZERLAND
"Bioartificial Organs: Clinical Trials"

Yoshihito Osada
Hokkaido University, Sapporo, JAPAN
"Intelligent Gels - Their Dynamism and Biomedical Applications"

Opening Reception

Sunday, July 19, 1998

07:00 - 08:30 Breakfast

08:30 - 12:30 (2) Plenary Session II: Bioartificial Pancreas
Co-chairs: Tobias Zekorn and Gerard Reach

Anthony Sun
University of Toronto, Toronto, CANADA
"Evaluation of Immunoisolated Insulin-Secreting STC6-F7 Cells As A Bioartificial Pancreas"

Riccardo Calafiore
University of Perugia, ITALY
"Minimal Volume Microcapsules as a Bioartificial Pancreas"

Gerard Reach
INSERM, Paris, FRANCE
"Current and Emerging Issues Related to the Bioartificial Pancreas"

Coffee Break

Tobias Zekorn
Justus-Liebig University, Giessen, GERMANY
"Metabolic Control After Intraperitoneal Transplantation of Microencapsulated Islet in Diabetic Rats"

David Hunkeler
Swiss Federal Institute of Technology, Lausanne, SWITZERLAND
"Polymers for Islet Encapsulation"

12:30 - 14:00 Lunch

14:00 - 17:30 Ad hoc sessions/free time

17:30 - 19:00 Dinner

19:00 (3) Tissue Sources: Xeno- versus Allografts
Co-chairs: T.Loudovaris (Baxter) and Julia E. Babensee (Rice Univ.)

Simon R. Robson and Fritz H. Bach
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
"Factors in Xenograft Rejection"

Collin Weber
Emory University, Atlanta, Georgia, USA
"Evaluation of Graft-Host Responses for Various Tissue Sources and Animal Models"

Greg Korbutt
Surgical-Medical Research Institute, University of Alberta, CANADA
"Neonatal Porcine Pancreas as a Source of Tissue for Islets"

Shimon Efrat
Albert Einstein College of Medicine, New York, USA
"Genetically engineered pancreatic cell-lines for cell therapy of diabetes"

Bernard Thorens
CHUV, Lausanne, SWITZERLAND
"Encapsulated Genetically Engineered Cells, Secreting Glucagon-like Peptide-1 for the Treatment of Non-insulin-independent Diabetes Mellitus"

Social Hour

Monday, July 20, 1998

07:00 - 08:30 Breakfast

08:30 - 12:30 (4) Plenary Session II: Processing and Technology
Co-Chairs: Michael Sefton and Clark Colton

Michael A. May and Michael Sefton
University of Toronto, Toronto, Canada
"Conformed Coating of Cell Aggregates in Hema-MMA"

Clark Colton
MIT, Cambridge, MA, USA
"Engineering Aspects of Cell Encapsulation and Survivability"

Mookie Sternberg
Baxter International, Inc., Round Lake, Illinois USA
"Membranes for Immunoisolation"

Rebecca H. Li
Cyto-Therapeutics Inc., Lincoln, Rhode Island, USA
"Scaffolds and Matrices for Membrane-based Artificial Organ Devices"

12:30 - 14:00 Lunch

Monday Lunch Talk
To be announced

14:00 - 18:00 (5a) Panel Discussion on Scale Up and Related Issues
Moderator: David Hunkeler

Panelists:
Robert Lanza
BioHybrid Technologies
Expertise: General

Theo Goosen
Oman
Expertise: Physico-Chemical Considerations in Microencapsulation

Dawn Applegate
Advanced Tissue Sciences, La Jolla, CA
Expertise: Tissue Banking

Horst Dautzenberg
University of Potsdam, Teltow, Germany
Expertise: Capsule Mechanical Properties

David W. Scharp
Neocrin, Inc., Irvine, CA
Expertise: Cell Implantation and Immunoprotection

Clark K. Colton
MIT, Cambridge, MA
Expertise: Optimization of Capsule Design and Regulation

Coffee

(5b) Oral and Craniofacial Related Issues
Chair: Eleni Kousvelari

Kevin Healy
Northwestern University, Chicago, Illinois, USA
"Biomimtic Materials that Regulate Tissue Formation"

Bruce Baum
National Institutes of Health, Bethesda, Maryland, USA
"Re-Engineering the Functions of A Terminally Differentiated Epithelial Cell in Vivo"

Herbert Waite
University of Delaware, Newark, Delaware, USA
"Reverse Engineering of Bioadhesion in Marine Mussels"

Jeffrey Hollinger
Oregon Health Sciences University, Portland, Oregon, USA
"Tissue Engineering of Bone in the Craniofacial Complex"

18:00 - 19:00 Poster Session and Social Hour

19:00 - 20:30 Dinner

20:30 - 21:30 Social Hour

Tuesday, July 21, 1998

07:00 - 08:30 Breakfast

08:30 (6) Molecular Aspects in the Prevention of Recognition and New Biomaterials
Co-chairs: Ron G. Gill and Ray V. Rajotte

Lola Reid
University of North Carolina, Chapel Hill, NC
Cell Matrix and Gene Expression

Ron G. Gill
Barbara Davis Center for Childhood Diabetes, University of Colorado "Antigen presentation pathways in allograft and xenograft rejection" or
"Factors which Influence T-cell Mortality in Membranes"

Terry Fetterhoff
Roche/Boehringer Mannheim
"Problems of Enzymatic Tissue Dissociation and Development of Standardized Reagents"

Hiroo Iwata
Kyoto University, Kyoto, JAPAN
"Agarose for Bioartificial Organs"

Paul Dubin
Indiana-Purdue University, Indianapolis, Indiana, USA
"Protein-Polyelectrolyte Coacervates"

12:30 - 14:00 Lunch

14:00 - 17:30 Ad hoc sessions/free time

17:30 - 20:00 Dinner
Lifetime Award Ceremony and Dinner Talk
Recipient selected by Awards Committee
(Alan Cherrington, Chair)

20:00 - (7) Bioartificial Liver: Implants and Extracorporeal Cellular Devices
Co-chairs: Achilles Demetriou and C. Mullon

C. Mullon
Circe Biomedical, Inc. (Division of Grace), Lexington, Massachusetts, USA
"Overview of Extracorporeal Liver Support Systems"

Jacek Rozga and Achilles A. Demetriou
Cedars-Sinai Medica Center, Los Angeles, California, USA
"Designing the Best Cell for Liver Support"

Jörg C. Gerlach
Humboldt University, Berlin, GERMANY
"The Challenge of Reproducing Liver Architecture and Function in Vitro"

J.F. Patzer II, G.V. Mazariegos, R. Lopez, E. Molmenti, D. Gerber, F. Differvold, A. Khanna, Y. Chen, W-Y Yin, V.L. Scott, S. Aggarwal, D.J. Kramer, R.A. Wagner, M.L. Fulmer, G.D. Block, B.P. Amiot (1)
University of Pittsburgh. Pittsburgh, Pennsylvania, USA
(1) Excorp Medical, Inc., Oakdale, Minnesota, USA
"Novel Bioartificial Liver Assist Device (BLAD): Preclinical Evaluation"

Achilles A. Demetriou
Cedars-Sinai Medical Center, Los Angeles, California, USA
"Experience with a Bioartificial Liver: Clinical Study Design Issues"

Wednesday, July 22, 1998

07:00 - 08:30 Breakfast

08:30 (8) Bioartificial Skin, Bone and Cartilage
Co-chairs: Gail Naughton and Ales Prokop

H. Uludag (1), W. Friess (2), D. Williams, G. Timony, D. D'Augusta
C. Sargent, B. Biron, J. Wozney
Genetics Institute, Andover, Massachusetts, USA
(1) University of Alberta, Edmonton, Alberta, CANADA
(2) Technical University of Erlangen-Nurnberg, Erlangen, GERMANY
"rhBMP/COLLAGEN SPONGES AS OSTEOINDUCTIVE DEVICES: EFFECTS OF SPONGE CHARACTERISTICS AND PROTEIN pl ON in vivo rhBMP PHARMACOKINETICS"

Jiri Prenosil
ETH, Zurich, SWITZERLAND
"Engineering Aspects of Large Scale Production of Cultured Skin Grafts: A Novel Computer Controlled Bioreactor"

Coffee Break

Gail Naughton
Advanced Tissue Sciences
"Cartilage Constructs in Tissue Engineering"

Arnold Caplan
Case Western University (To be confirmed)
"Tissue Engineered Bone for Orthopedic Applications"

Kermit Borland, Tao Zhou, Jim Birkhead, Deb Deane and Dan Omstead
Reprogenesis, Inc., Cambridge, Massachusetts, USA
"Injectable Hydrogels Containing Autologous Chondrocytes As Engineered Tissue Bulking Agents"

12:00 Concluding Remarks
David Hunkeler

12:30 Lunch and Departure

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POSTER PRESENTATIONS

(Through 28 April. Additional presentations are welcomed.)

CHARACTERIZATION OF PROCINE HEPATOCYTE DETOXIFICATION ACTIVITY
Paul G. Gregory, Christopher K. Connolly and Susan J. Sullivan
Organogenesis, Inc.. Canton, Massachusetts, USA;
Kamelia Behnia and Mehmet Toner
Massachusetts General Hospital, Shriners Hospitals for Children and Harvard Medical School, Boston, Massachusetts, USA

CHARACTERIZATION OF INSULIN SECRETION FROM ISLET CELL LINES ENCAPSULATED IN P-L-L AND CHITOSAN MICROSPHERES
Cynthia B. Elias, William B. Perry, and Dhinakar S. Kompala
University of Colorado, Boulder, Colorado, USA

INJECTABLE HYDROGELS CONTAINING AUTOLOGOUS CHONDROCYTES AS ENGINEERED TISSUE BULKING AGENTS
Kermit Borland, Tao Zhou, Jim Birkhead, Deb Deane and Dan Omstead
Reprogenesis, Inc., Cambridge, Massachusetts, USA

IMPORTANCE OF EXTRACORPOREAL CIRCULATION RATE IN BIOARTIFICIAL LIVER
H. Iwata, Y.G. Park, and Y. Ikada
Kyoto University, Kyoto, JAPAN

NOVEL BIOARTIFICIAL LIVER ASSIST DEVICE (BLAD): PRECLINICAL EVALUATION
J.F. Patzer II, G.V. Mazariegos, R. Lopez, E. Molmenti, D. Gerber, F. Differvold, A. Khanna, Y. Chen, W-Y Yin, V.L. Scott, S. Aggarwal, D.J. Kramer, R.A. Wagner, M.L. Fulmer, G.D. Block, B.P. Amiot (1)
University of Pittsburgh. Pittsburgh, Pennsylvania, USA
(1) Excorp Medical, Inc., Oakdale, Minnesota, USA

rhBMP/COLLAGEN SPONGES AS OSTEOINDUCTIVE DEVICES: EFFECTS OF SPONGE CHARACTERISTICS AND PROTEIN pl ON in vivo rhBMP PHARMACOKINETICS
H. Uludag (1), W. Friess (2), D. Williams, G. Timony, D. D'Augusta, C. Sargent, B. Biron, J. Wozney
Genetics Institute, Andover, Massachusetts, USA
(1) University of Alberta, Edmonton, Alberta, CANADA
(2) Technical University of Erlangen-Nurnberg, Erlangen, GERMANY

PLATELET ADHESION
Anand Ramamurthi and Randy S. Lewis
Oklahoma State University, Stillwater, Oklahoma, USA

DESIGNED NETWORKS FOR IMMUNOISOLATION
J.P. Kennedy (1) and G. Fenyvesi (1), R.P. Levy (2), and K.S. Rosenthal (3)
(1) The University of Akron, Akron, Ohio, USA
(2) Endocrine Associates, Akron, Ohio, USA
(3) NEOUCOM, Rooststown, Ohio, USA

NEW THERAPEUTIC RELEVANCE OF CELLULOS SULPHASE CAPSULES THROUGH ESTABLISHMENT OF A MANUFACTURING PROCESS
Saller, R.M. (1), Lohr, J.M. (2), Muller, P. (1), Pelegrin, M. (3), Dautzenberg, H. (4), Pluss, R. (5), Bauch, H. (6), Hutzler (7), Salmons, B. (1)
(1) Bavarian Nordic Research Institute, Martinsried, GERMANY
(2) Universitatsklinik Rostock, Rostock, GERMANY
(3) Institut de Genetique Moleculaire de Montpellier, Montpellier, FRANCE
(4) Universitat Potsdam, Teltow, GERMANY
(5) INOTECH, Dottikon, SWITZERLAND
(6) Carl Zeiss Vision, Eching, GERMANY
(7) Institute for Pathology, Oberschleissheim, GERMANY

PREPARATION OF REUSABLE BIOSORBENT FROM Zoogloea ramigera CELLS FOR CADMIUM REMOVAL
Joong Kon Park (1), Yong Biao Jin (1) and Ho Nam Chang (2)
(1) Kyungpook National Universitry, Taegu, KOREA
(2) KAIST, Taejon, KOREA

FETAL PIG ISLET CELL CLUSTERS: IN VITRO CULTURE CONDITIONS TO PROMOTE SURVIVAL AND DIFFERENTIATION
R.P. Muirhead, S. Holman, AM Simpson, and B.E. Tuch
Prince of Wales Hospital, Sydney, AUSTRALIA

IMPROVED STABILITY AND PERMEABILITY CONTROL FOR ALGINATE-CHITOSAN MICROCAPSULES
Olav Gåserød and Gudmund Skjåk-Bræk
Norwegian University of Science and Technology, Trondheim, NORWAY

GRAFTING OF CULTURED KERATINOCYTES ON POLYMER SUPPORT
K. Smetana, Jr. (1,4), B. Dvorankova (2), R. Konigova (2), H. Singerova (2), Z. Kapounkova (2), M. Andel (3), E. Cincarova (2), J. Vacik (4) and J. Labsky (4)
(1) Institute of Anatomy, First Faculty of Medicine, Charles University, 128 00 Prague 2
(2) Prague Burn Center
(3) Second Department of Internal Medicine, 3rd Faculty of Medicine, Charles University, Prague
(4) Institute of Macromolecular Chemisty, Academy of Sciences of the Czech Republic

ISLET IMMUNOISOLATION: IN VITRO METRICS AND IN VIVO FUNCTION
Artur Bartkowiak and David Hunkeler
Swiss Federal Institute of Technology, Lausanne, SWITZERLAND

THREE-DIMENSIONAL IN VIRTO CELL CULTURE LEADS TO A MARKED UPREGULATION OF CELL FUNCTION IN HYUMAN HEPATOCYTE CELL LINES: AN IMPORTANT TOOL FOR THE DEVELOPMENT OF A BIOARTIFICIAL LIVER MACHINE
Clare Selden, Ali Shariat, Paschal McCloskey, Tim Ryder, Eve Roberts, and Humphrey Hodgson
Imperial College of Medicine, London, ENGLAND

DESIGN AND TESTING OF THE HEPATASSISTTM HYBRID ARTIFICIAL LIVER SYSTEM
Linda Custer, Claudy Mullon
Circe Biomedical, Inc., Lexington, Massachusetts, USA

CULTIVATION AND CHARACTERIZATION OF A NEW IMMORTILIZED HUMAN HEPATOCYTE CELL LINE HepZ FOR THE USAGE IN AN ARTIFICIAL LIVER SUPPORT SYSTEM
Andreas Werner, Jürgen Lehmann
University of Bielefeld, Bielefeld, GERMANY

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