PRELIMINARY PROGRAM

ADVANCES IN OPTICS
FOR
BIOTECHNOLOGY, MEDICINE AND SURGERY

1 - 6 August 1999
Kona Surf Resort and Conference Center
78-128 Ehukai Street
Kailua-Kona, Hawaii 96740
Phone: 1-808-322-3411

Conference Co-Chairs:
Dr. David Benaron
Stanford University

Dr. Eva M. Sevick-Muraca
Purdue University

Dr. Arjun G. Yodh
University of Pennsylvania

United Engineering Foundation, Inc.
Three Park Avenue, 27th Floor
New York, NY 10016-5902
T: 1-212-591-7836 F: 1-212-591-7441
E-mail: engfnd@aol.com WWW: http://www.engfnd.org

Posters

Sunday, August 1, 1999

4:00 p.m. - 6:00 p.m. Registration

6:00 p.m. - 7:30 p.m. Dinner

7:30 p.m. - 7:45 p.m. Opening Remarks
SESSION I: PHOTODYNAMIC THERAPY: FUNDAMENTAL AND CLINICAL
STUDIES
Session Chair: Tayyaba Hassan, Wellman Laboratories

8:00 p.m. - 8:30 p.m. An Overview of Photodynamic Therapy Mechanisms
D. Kessel, Wayne State University School of Medicine

8:30 p.m. - 9:00 p.m. Photodymanic Therapy for the Treatment of Age-Related
Macular Degeneration
J. Levy, QLT PhotoTherapeutics, Inc.

9:00 p.m. - 9:30 p.m. Cardiovascular Applications of Photodynamic Therapy
K. Woodburn, Pharmacyclics

9:30 p.m. - 10:00 p.m. Photodynamic Therapy with Levulan® and a Primer on the
FDA Approval Process
S.L. Marcus, DUSA Pharmaceuticals, Inc.

10:00 p.m. - 11:00 p.m. Social Hour

Monday, August 2, 1999

7:00 a.m. - 8:30 a.m. Breakfast

SESSION II: FRONTIERS FOR SPECTROSCOPY: IN VITRO DIAGNOSTIC
Session Chair: Rebecca Richards-Kortum, University of Texas at Austin

8:30 a.m. - 9:00 a.m. Quantitative Biomarkers: Risk of Progression and Role in
Cancer Chemoprevention Trials
C.W. Boone, National Institute of Health, Bethesda

9:00 a.m. - 9:30 a.m. Biological Basis of Cervical Tissue Fluorescence and
Correlation with Biomarkers
M. Follen Mitchell, MD Anderson Cancer Center, Houston

9:30 a.m. - 10:00 a.m. Biological Basis of Bronchial Tissue Autofluorescence and
Correlation with Biomarkers
S. Lam, British Columbia Cancer Agency, Vancouver

10:00 a.m. - 10:30 a.m. Coffee Break

10:30 a.m. - 11:00 a.m. Multi-Spectral Reflectance Imaging of the Cervix in Vivo
B. Pogue, Darmouth

11:00 a.m. - 12:00 noon Discussion

12:00 noon - 1:30 p.m. Lunch

1:45 p.m. - 5:45 p.m. Ad hoc sessions and/or free time

5:45 p.m. - 7:15 p.m. Dinner

SESSION III: FRONTIERS IN SPECTROSCOPY: TISSUES
Session Chair: Michael Feld, Massachusetts Institute of Technology

7:30 p.m. - 8:00 p.m. Neural Network Assisted Analysis for Screening Cervical
Smears
L.J. Mango, Neuromedical Systems

8:00 p.m.- 8:30 p.m. NIR Reflectance Spectroscopy for Glucose Measurement
M. Arnold, University of Iowa

8:30 p.m. - 9:00 p.m. Coffee Break 9:00 p.m. - 9:30 p.m. Relationship Between Spectroscopy and Pathology Mary Ann Fitzmaurice, Case Western Reserve University & University Hospitals, Cleveland

9:30 p.m. - 10:00 p.m. PANEL DISCUSSION
Fluorescence, Reflectance or Raman: Which is better technique? Fluorescence! Tuan Vo Dinh, Oak Ridge National Laboratory Reflectance! Irving Bigio, Los Alamos National Laboraory TBA D. Bornhop

10:00 p.m. - 11:00 p.m. Social Hour

Tuesday, August 3, 1999

7:00 a.m. - 8:30 a.m. Breakfast

SESSION IV: PHOTON MIGRATION
Session Chair: Bruce Tromberg, Beckman Laser Institute, University of California at Irvine

8:30 a.m. - 9:00 a.m. Continuous Bedside Monitoring and Imaging of Brain
Oxygenation
D.T. Delpy, Department of Medical Physics & Bioengineering, University College London

9:00 a.m. - 9:30 a.m. Laser Mammography and Non-Invasive Optical Monitoring of
Cerebral Activity
S. Fantini, Department of Physics, University of Illinois at Urbana-Champaign

9:30 a.m. - 10:00 a.m. Photon Migration Imaging and Spectroscopy
M.S. Patterson, Hamilton Cancer Center

10:00 a.m. - 10:30 a.m. Coffee Break

10:30 a.m. - 11:00 a.m. Optical Mammography
D. Boas, Harvard University

11:00 a.m. - 12:00 noon Panel Discussion
B. Chance, University of Pennsylvania

12:00 noon - 1:30 p.m. Lunch

1:45 p.m. - 5:30 p.m. Ad hoc sessions and/or free time

5:45 p.m. - 7:15 p.m. Dinner

SESSION V: ADVANCES IN TISSUE MICROSCOPY, DYES AND
REPORTERS
Session Chair: Robert Webb, Massachusetts General Hospital

7:30 p.m. - 8:00 p.m. The Best Current in Vivo Microscopy: Live Confocal
Microscopy
M. Rajadhyaksha, Lucid, Inc.

8:00 p.m. - 8:30 p.m. The Best Current Vital Imaging Via Catherer - OCT: A
Catherer-Delivered Optical Coherence Tomography Imager
B. Bouma, Wellman Laboratories of Photomedicine

8:30 p.m. - 9:00 p.m. Coffee Break

9:00 p.m. - 9:30 p.m. Luciferase Reporter Gene
C. Contag, Stanford University

9:30 p.m. - 10:00 p.m. Functional Genomics: An Introduction
M. Zoller, Ariad Pharmaceutics

10:00 p.m. - 11:00 p.m. Social Hour

Wednesday, August 4, 1999

7:00 a.m. - 8:30 a.m. Breakfast

SESSION VI: ADVANCES IN CELL MICROSCOPY: SPECTROSCOPY AND
MICROMANIPULATION
Session Chair: Daniel Farkas, University of Pittsburgh and Carnegie Mellon University

8:30 a.m. - 9:00 a.m. TBA
T. Yanagida, Osaka University

9:00 a.m. - 9:30 a.m. Labelling DNA for Sensitive Detection
A. Waggoner, Amersham Pharmacia

9:30 a.m. - 10:00 a.m. Coffee Break

10:00 a.m. - 10:30 a.m. TBA
S. Hell, Max Planck Institute for Biophysical Chemistry

10:30 a.m. - 11:00 a.m. TBA
T. Wilson, University of Oxford

11:00 a.m. - 12:00 noon Discussion

12:00 noon - 1:30 p.m. Lunch

2:30 p.m. - 5:30 p.m. POSTER SESSION

6:00 p.m. - 7:30 p.m. Dinner

SESSION VII: LASER-TISSUE INTERACTIONS: THERAPEUTIC
INTERVENTIONS
Session Chair: Steven Jacques, Oregon Laser Center

7:45 p.m. - 8:15 p.m. Laser Thermal Shaping of Cartilage Implants
B. Wong, Beckman Laser Institute

8:15 p.m. - 8:45 p.m. Laser Thrombolysis: Clearing Vessel Clots in Heart and
Brain
S. Prahl, Oregon Medical Laser Center

8:45 p.m. - 9:15 p.m. Coffee Break

9:15 p.m. - 9:45 p.m. Photochemically Activated Adhesives for Tissues
Anastamosis
M. Judy, Baylor Research Institute

9:45 p.m. - 10:15 p.m. Discussion

10:15 p.m. - 11:15 p.m. Social Hour

Thursday, August 5, 1999

7:00 a.m. - 8:30 a.m. Breakfast

SESSION VIII: OPTICS FOR BIOTECHNOLOGY
Session Chair: Tom Baer, Arcturus

8:30 a.m. - 9:00 a.m. Simultaneous 10 Channel Fluorescence Tagging and Flow
Cyometric Analysis of Leukocytes: Applications to Immune System Monitoring and HIV
M. Roederer, Stanford University

9:00 a.m. - 9:30 a.m. Gene Expression Analysis Using Laser Capture
Microdissection and Fluorescent cDNA Microarrays
M. Erlander, R.W. Johnson Pharmaceutical Institute

9:30 a.m. - 10:00 a.m. Coffee Break

10:00 a.m. - 10:30 a.m RNA/DNA Molecular Diagnostics: Applications to Cancer
Diagnosis
S. Bova

10:30 a.m. - 11:00 a.m. TBA
R. Bonner, National Institute of Health

11:00 a.m. - 12:00 noon Discussion

12:00 noon - 1:30 p.m. Lunch
LUNCHEON SPEAKER
D.S. Coffey, Johns Hopkins
Molecular Biology of Cancer: Vision of the Future

1:45 p.m. - 6:30 p.m. Ad hoc sessions and/or free time

7:00 p.m. - 10:30 p.m. Luau

Friday, August 6, 1999

7:00 a.m. - 8:30 a.m. Breakfast

SESSION IX: BIOMEDICAL OPTICS RESEARCH FOR THE 21ST CENTURY
Session Chair: Tom Deutsch, Wellman Laboratories, Massachusetts General Hospital

8:30 a.m. - 9:00 a.m. The Future of MR, PET and Optical Imaging
R. Lenkinski, University of Pennsylvania

9:00 a.m. - 9:30 a.m. Optics in Medicine
F. Hillenkamp, Muenster

9:30 a.m. - 10:00 a.m. Coffee Break

10:00 a.m. - 12:30 p.m. Industry Agency, Roundtable Discussion Including
Preparation of Meeting Summary by Chairs and Session Organizers

12:30 - 2:00 p.m. Lunch

2:00 p.m. - Conference adjournment

Posters
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